KKKR1034 FUNDAMENTAL OF CHEMICAL AND BIOCHEMICAL ENGINEERING Chemical and Biochemical Engineering Department REPORT TITLE:
PFD study of the Production of Isopropyl Alcohol. LECTURER’S NAME:
1. PROF. ABU BAKAR BIN MOHAMAD 2. DR. MANAL BINTI ISMAIL
Group Members CHONG KIN HOW MOHD AZIZAN BIN RAZAL @ ABD RAZI NORFATYHAH BINTI ABD. AZIZ NORASMANIRA BINTI MUSA NUR IZAYU BINTI BADARUDDIN
DATE OF SUBMISSION: 1st JUNE 2010
Matric no. A130043 A130463 A130473 A129780 A127653
ABSTRACT
The objective of the report is to study the process of production of isopropyl alcohol by using indirect hydration method. An improved process for indirect hydration of propylene to form Diisopropyl Ether and Isopropyl Alcohol is provided in which propylene is absorbed in Sulphuric acid to form an extract. It is withdrawn from the absorbing zone; water in carefully controlled amounts is mixed with the extract. While the resulting mixture is passed to an ether generating zone to form a vaporous ether product and a bottoms product depleted in Diisopropyl Ether containing Sulphuric acid in a concentration at least equal to the acid concentration in the extract withdrawn from the absorbing zone. The withdrawn bottoms is the divided into two portions: a first portion is recycled to the absorber; and the second such portion is mixed with sufficient water to hydrate absorbed olefin values and the resulting mixture is fed to an alcohol generator for formation of isopropyl alcohol as overhead product and dilute Sulphuric acid as bottoms product.
TABLE OF CONTENT
No. 1
Item
Page
Introduction 1.1 Physical properties of IPA 1.2 Chemical properties of IPA 1.3 Production of IPA 1.4 Uses and application of IPA 1.5 Health and Safety Factor 1.6 Isopropyl Alcohol nowadays
2 2 3 5 7 7
Process Flow Diagram (PFD) 2.1 Block diagram of production of Isopropyl alcohol 2.2 Process Flow Diagram of production of IPA 2.3 Description of process flow diagram of production of IPA
8 9 11
3
Conclusions
15
4
References
17
2
INTRODUCTION
The IUPAC name for chemical compound with the molecular formula of C3H8O is propan-2-ol. Other common names for this compound are isopropyl alcohol, isopropanol, 2propanol and rubbing alcohol. It is the simplest example of a secondary alcohol which the hydroxyl group (OH-) is attached to a carbon atom that is also attached to two other carbon atoms sometimes shown as (CH3)2CHOH. Besides, it is a structural isomer of propanol and in industry, the isopropyl alcohol is well known as IPA. 1.1. Physical Properties of IPA
Some of the physical properties of isopropyl alcohol are it is colorless liquid at room temperature, the molar mass is approximately 60.09 g mol−1, have strong rubbing alcohol odor, miscible in water, soluble in some organic solvent but insoluble in salt solution and it is also fairly volatile (evaporates easily). The melting point of this chemical compound is -890C whereas the boiling point is 82.50C. Anhydrous IPA has density about 0.7854g/cm3 whereas the 91% vol IPA have a density of 0.8173 g/cm 3. 1.2. Chemical properties of IPA
Chemical properties of isopropyl alcohol are determined by its functional hydroxyl group in the secondary position. Except for the production of acetone, most isopropyl alcohol chemistry involves the introduction of the isopropyl or isopropoxy group into other organic molecules by the breaking of the C – OH or the O – H bonding the isopropyl alcohol molecule. Isopropyl alcohol undergoes reactions typical of an active secondary alcohol. Some of the chemical property of this alcohol is it can be separated from its aqueous solutions by adding a salt such as sodium chloride, potassium chloride, or any of several other inorganic salts. This is due to solubility of this alcohol in saline which is less compared to its solubility in salt-free water.
Besides, IPA may undergo dehydrogenation process. Dehydrogenation of isopropyl alcohol to acetone was the most widely practiced production method in industry. This reaction is endothermic reaction means it absorbs about 66.5kJ/mol of heat and occurs at temperature range between 300-5000C. The most useful catalyst contains Cu, Zn, Cr, and Ni as oxides can be used to increase the reaction rate. The balance chemical equation of the dehydrogenation process:
100-200kPa
(CH3)2CHOH
→ CH3COCH3 + H2
Chemically, secondary alcohol can be catalytically oxidized using air or oxygen at high temperature (400−600◦C) to form respectively ketone and water. Here, when isopropyl alcohol undergoes oxidation process, the product is acetone. The preferred catalyst for this reaction is zinc chloride, ZnO. The oxidation process is highly exothermic which means this reaction releases large amount of energy usually in the form of heat
(CH3)2CHOH + 0.5O2 → CH3COCH3 + H2O acetone
Furthermore IPA reacts with active metal such as potassium to form alkoxides. Next, isopropyl alcohol can be dehydrated in either the liquid phase over acidic catalysts, eg, sulfuric acid, or in the vapor phase over acidic aluminas to give diisopropyl ether. This reaction is known as etherification. IPA also undergoes halogenation chemical reaction with halogen compound. Normally, 2-halopropane derivatives are prepared from isopropyl alcohol most economically by reaction with the corresponding acid halide. However, under appropriate conditions, other reagents, eg, phosphorus halides and elemental halogen also react by replacement of the hydroxyl group to give the halide. Normally, this reaction temperature is about 650C. 3(CH3)2CHOH + PBr 3 → (CH3)2CHBr + H 3PO3 2-halo ro ane
1.3.Production of IPA
In industry, many methods can be carried out to produce isopropyl alcohol. The hydrolysis of haloalkanes is one of the examples. Here, a secondary haloalkane is used for instance 2-bromopropane. This haloalkane is than being reacted with an aqueous solution of base or alkali (e.g: sodium hydroxide, NaOH). The product of this reaction is secondary alcohol and halide ion in this case the isopropyl alcohol and bromide ion. Other technique is by the addition of Grignard Reagent to carbonyl compound. But chemically, the most beneficial way usually being performed to produce isopropyl alcohol in large amount is by hydration process. In general, hydration reaction is a chemical reaction in which a hydroxyl group (OH-) and a hydrogen cation are added to the
two carbon atoms bonded together in the carbon-carbon double bond which makes up an alkene functional group. In order to obtain isopropyl alcohol as the major product, an alkene called propene is used.
There are two processes to produce isopropyl alcohol by combining water and propene. One is direct hydration by reacting propene-containing hydrocarbon stream with water either in gas or liquid phases at high pressures with the presence of a strongly heterogeneous polymeric acid, solid hydration catalyst, preferably a cation exchange resin catalyst. The catalyst is used to increase the rate of reaction but the catalyst itself do not consumed in the reaction. Since the addition of sulphuric acid or water to propene follow Markovnikov’s rule
which state that when a molecule HX is added across a carbon-carbon double bond, the hydrogen ion from HX will joins to the carbon atom which is already has the more hydrogen atoms attached to it, this process give propan-2-ol as the main product rather than 1-propanol that will be the side product. This process requires high-quality propene than is represented by simple chemical equation follow: CH3CH=CH2 + H2O ↔ CH3CH(OH)CH3 Second method is indirect hydration with sulfuric acid. This is the most common route to produce IPA. The alkene is hydrated to alcohols by a two stage process. First stage is the process of reacting propene with sulphuric acid to form a mixture of sulphate esters named isopropyl hydrogen sulphate and diisopropyl sulfate. It can be said that the sulphuric acid will be functioning as catalyst. The esterification of propene with sulphuric acid is conducted in apparatus called absorber and takes place at low temperature, usually below 70°C. This process is corrosive and is energy demanding for acid re-concentration and aqueous waste treatment. The chemical reactions occur is represented by balanced chemical equation: CH3CH=CH2 + H2SO4 → (CH3)2CHOSO3H Isopropyl hydrogen sulphate
(CH3)2CHOSO3 + CH3CH=CH2 → ((CH3)2CH)2SO2 diisopropyl sulfate
And the final stage is the hydrolysis of these esters to produces isopropyl alcohol. The hydrolysis process occurs in which a certain molecule is split into two parts by the addition of
a molecule of water. Here, the addition of water to the mixture of isopropyl sulphate and diisopropyl sulfate yield IPA and sulphuric acids respectively. The machine in which the hydrolysis process is conducted is known as hydrolyzers. As with the direct hydration method, some byproducts are either being recycle or set aside. CH3CH(OSO3H)CH3 + (CH3)2CH(OSO3)CH(CH3)2 + 2H2O →
3CH3CH(OH)CH3 +
2H2SO4 This complex process is known as ‘strong -acid processes’ and to obtain the product, low -
quality propene can be used. Both direct and indirect hydration reaction processes require that the isopropyl alcohol be separated from water and other side products by distillation. Isopropyl alcohol and water form an azeotrope and simple distillation gives a material which is 87.9% by weight isopropyl alcohol and 12.1% by weight water. Azeotrope is a mixture of two or more liquids in such a ratio that its composition cannot be changed by simple distillation. Pure isopropyl alcohol is made by azeotropic distillation of the "wet" isopropyl alcohol using either diisopropyl ether or cyclohexane as azeotroping agents. Azeotropic distillation refers to the specific technique of adding another component to generate a new, lower-boiling azeotrope that is heterogeneous. 1.4.Uses and application of IPA
Light branched alcohols are produced by the addition of alkene or olefin and water under an acid catalyst. Isopropyl alcohol is consumed as a direct solvent for half of its production in the world. It has many applications in our daily lives. This alcohol is mainly use as antifreeze or a solvent. The use of isopropyl alcohol as a feedstock for the production of acetone is expected to remain stable, as the dominant process for acetone is cumene oxidation. Isopropyl alcohol is also consumed in the production of other chemicals such as methyl ketone, isopropylamine, and isopropyl acetate. The use of diisopropyl ether as a fuel ether may become significant outlet for isopropyl alcohol. Additional valuable application is in pharmaceutical industry. IPA is widely use as an antiseptic medication due to the quickly-evaporate properties of this compound. This alcohol
temporarily sterilizing wounds and the areas around it, once the isopropyl alcohol evaporates, the wounded area is again open to infection and disease. In building construction field as well as in agriculture, isopropyl alcohol also has its own uses. In construction field, Isoproyl alcohol forms many important compounds used to create wood finish, such as acetone, shellac solvent and drying inks. Shellacs give wood a smoother and darker look, often more desirable than lighter colors. The actual shellac comes in flakes that need to dissolve in a denatured alcohol such as isopropyl. The acetone formed from isopropyl is commonly used to remove nail polish and other paints. In plantation industry, the isopropyl alcohol is widely used as pesticides. Agricultural business uses IPA as a great compound to kill unwanted insects and parasites by using it as an adjuvant. An adjuvant in agricultural pesticides and herbicides is a solution added to help the pesticide spread evenly across the plant or slow the uptake of the chemical this is because some plants may not be able to absorb enough pure pesticide before it evaporates. The adjuvant mixes with pesticide without changing any chemical properties. Isopropyl alcohol is also employed widely as a solvent for cosmetics for examples lotions, perfumes, shampoos, skin cleaners, nail polishes, makeup removers, deodorants and body oils. In cosmetics applications, the acetone-like odor of IPA is masked by the addition of fragrance. Aerosol that contain isopropyl alcohol solvent formulation include hair sprays, floor detergents, shoe polishes, window cleaners, waxes and polishes, paints, automotive products and fabric-wrinkle remover are commonly used every day. Other daily uses of isopropyl alcohol is it works great at removing any sticky residue, such as hair spray, from mirrors or glass, remove stain as a result from permanent marker and can be use to wipe CDs or DVDs to remove stains and smudges without harming data.
1.5.Health and Safety Factor
Alcohols as a class have low toxicity. IPA is about twice as toxic as ethyl alcohol but less toxic than methyl alcohol. Toxic doses of ingested IPA usually as rubbing alcohol may produce narcosis, anesthesia, coma and death. Use of alcohol in industrial application does not present a health hazard. The alcohol produces anesthetic in high vapor concentration. There is some safety procedures should be take into consideration while working with IPA. Since IPA is highly flammable with a wide range of combustibility, it should be kept away from heat, open flame, ignition sources and incompatibles. Isopropyl alcohol can explode if it is mixed with excessive air or other oxidizer through deflagration since these agent support combustion. Like many other organic solvents, when the isopropyl alcohol is in contact with human skin for a long period, defatting can occur. Deffating is a skin condition similar to inflammation of the skin resulting from the chronic exposure of human skin to alcohols, detergents, chemical solvent and motor oil. Therefore, while handling the pure IPA in the laboratory, appropriate protective clothing should be wear such as gloves, lab coats and aprons. 1.6.Isopropyl Alcohol nowadays
Asian isopropanol (IPA) spot prices rose $10-20/tonne across the region, supported by the rebound in upstream crude values and firm feedstock propylene values during the week. Price targets for remaining November IPA shipments remained at $1,020-1,050/tonne Council of Foreign Relation Asia although trade was limited particularly in China as sellers and buyers kept to the sidelines. In early May 2010, the Asian Market review shows that the price of IPA has rose by 5% compared to its price in mid-April. It is from $1200/tonne to $1240/tonne. Operating with the brand name ‘Recycled IPA’, one of the companies that manufacture
and distribute isopropyl alcohol in Malaysia is Geo Chem Trading located in Penang Port, Butterworth Penang. Other products available are recycled solvent, toluene, acetone, xylene and many more.
PROCESS FLOW DIAGRAM 2.1.Block diagram of the production of Isopropyl Alcohol
The block diagram is the simplest form to show the production of some material. In chemical or biochemical industries, the block diagram shows the first impression of the production of some agent or products. The figure 1 below shows the block diagram of production of Isopropyl Alcohol or IPA by indirect hydrolysis process. INPUT (RAW MATERIAL) -SULPHURIC ACIDS - PROPYLENE GAS
REACTION OF SULPHURIC ACID WITH PROPYLENE
MIXER CHAMBERWATER FEED
FLASH ZONE SEPARATION
MIXING CHAMBERWATER FEED
ACID RECONCENTRATION -RECYCLED
IPA GENERATION
DISTILLATION COLUMN -ETHER COLUMN -DRIYING COLUMN
OUTPUT -DIISOPROPYL ETHER -ISOPROPYL ALCOHOL IN CDM AND ANHYDROUS
Figure 1-block diagram of isopropyl alcohol
UNABSORBED PROPELYNE GASRECYCLED
Based on the figure1 above, it shows that the raw materials that will be used are the Sulphuric acids and the propyelene gas. After that, it will react and producing and extract mixture called Isopropyl Sulphuric Ester in certain condition. After that, it will face to hydrolysis process with water to produce certain amount of IPA with the by-product of Diiisopropyl Ether. The flash zone is called as the separator that will separate the product in gases and liquids. The gas contains some concentration of IPA and Diisopropyl Ether while the depleted liquid is consisting of some mixture of Propelyene and also Sulphuric Acids. Next, it will undergo the second hydrolysis in the second mixing chamber with water to produce some ratio of IPA and the by-product of Ether. Then, the IPA generation will separate the mixture of liquid from the second mixing chamber. The acids that is separate will be reconcentrated and recycled as raw materials. The product of IPA and Diisopropyl Ether will be undergo a distillation process. In the distillation process, the crude IPA will be distillate and produces the anhydrous IPA as the final product of process. The detail of the production of IPA will be explain in the Process Flow Diagram. 2.2.Process flow diagram of production of Isopropyl Alcohol
The Process Flow Diagram (PFD) of the production of Isopropyl alcohol is shown in figure 2. Noted that the process flow diagram is the indirect hydrolysis of Isopropyl Alcohol production.
2.3.Description of Process flow diagram of Isopropyl Alcohol
In figure 1, it shows the summary of the production of Isopropyl Alcohol that be used in some of other company nowadays. Next, in figure2 it shows the Process flow diagram of production of IPA in the chemical or biochemical plant in the industries. Below are the briefly explanation and description regarding the production of IPA by indirect hydrolysis based on the process flow diagram.
1. Concentrated sulphuric acid from about 60 to 70 wt% feed stream 1 mixes with stream 2 in the absorber C100. Stream 2 feed with 45 wt% of propylene gases (PP). PP may be obtained from various sources such as destructive distillation of carbonaceous materials, but particularly from the cracking of petroleum hydrocarbon. Absorber C100 is operated at a pressure from about 150 to 300 psig and a temperature within the range 85 to 1150C.
2. An extract liquid is formed in the absorber C100 comprising from about 40 to 65 wt% of sulphuric acid, from about 10 to 40 wt% of absorbed propylene values and the balance water. Absorbed propylene values refer to all molecules in the liquid which contain propyl (C3H7), and propylene (C3H6) moieties such as propyl ester, isopropyl alcohol from about 10 to 45 wt%, and diisopropyl ether from about 3 to 6 wt%. The extract liquid is withdrawn from the bottom portion of absorber via Stream 3 to the mixer M100.
3. Unabsorbed gases, propylene are withdrawn and being compressed by C100 from the upper portion of the absorber to the propylene column C104 via stream 4. In the propylene column C104, propylene is refined to get recovered propylene and send back via stream 5 into stream 2 to be recirculated into the absorber. While at the lower portion of column, propane is withdrawn through stream 6.
4. In the mixer M100, stream 3 mixes stream 7 which feed with water. Water is added in an amount from about 1.5 to 6 wt% water, based on the weight of absorbed propylene values in the extract liquid to provide the moles of water stoichiometrically required to form the amount of diisopropyl ether and isopropyl alcohol withdrawn as vapor in the flash vessel C101.
5. The resulting mixture in the M100 is piped to flash vessel C101 via stream 8. Flash vessel C101 is operated at a temperature range between 80 to 1600C and a pressure from about 5 to 10 psig. From flash vessel, the overhead vapor is withdrawn and being compressed by C101 via stream 10 comprising diisipropyl ether from about 30 to 50 wt%, isopropyl alcohol from about 30 to 40 wt%, and propylene from about 10 to 20 wt%. Liquid which is withdrawn from the flash vessel via stream 9 comprises the depleted extract contains absorbed propylene values from about 5 to 35 wt%, sulphuric acid from about 45 to 65 wt% and balance water.
6. Depleted extract is divided into two portions. A first portion is send via stream 11 and 1 and through pump P100 to the absorber C100 as recycle. This portion comprises from about 40 to 60 wt% of the total depleted extract. A control valve V100 is used to increase or decrease the liquid split ratio of mass flow rate of liquid in stream 11 and mass flow rate of liquid in stream 12. This valve is used to control diisopropyl ether and isopropyl alcohol production. The second portion which is from the remaining depleted extract is send via stream 12 to the second water mixing zone, mixer M101.
7. In the mixer M101, the depleted extract mixes stream 13 which feed with water. The amount of water feed is from about 35 to 100 parts by weight of water per part by weight of absorbed propylene values in the depleted extract. The liquid residence time in water mixing zone ranges from about 1 to 30 minutes.
8. The resulting aqueous mixture in mixer is send through stream 14 to alcohol generator C102 to be heated, as by means of direct injection of steam via stream 15. Alcohol generator C102 generally operated at a bottoms temperature of from about 70 to 1300C and a bottoms pressure from about 1 to 50 psig. In this generator, alcohol vapors are formed as overhead product and withdrawn, compressed via stream 17 into scrubber C103.
The vapors in stream 17 comprise isopropyl alcohol, diisopropyl ether and minor amount of propylene and water. Sulphuric acid from about 45 to 55 wt% is withdrawn from the lower portion of alcohol generator through stream 16 to the acid concentrator.
9. The product in the stream 17 and 10 mixes in scrubber C103 to be neutralized using sodium hydroxide, NaOH at concentration 10 wt.% NaOH. NaOH is used to neutralized the mixture of alcohol vapor and sulphuric acid and feed via stream 18. Scrubber is operated at a temperature of 373 K and a pressure of 14.7 psi. The crude alcohol product at 55% IPA is withdrawn from the lower part of scrubber C103 via stream 19 to crude isopropyl alcohol tank F100. From this tank, the mixture is send to the ether column C105 via stream 20 which is operated at a temperature of 362 K and a pressure of 14.7 psi. In this column distillation process will take place to separate diisopropyl ether and hexene. The overhead product, diisopropyl ether is withdrawn via stream 21 to the diisopropyl column C109. Then, it is washed to produce washed diisopropyl ether at 95 wt.%.
10. Wet isopropyl alcohol from lower part of ether column C105 is extract via stream 22 and feed into alcohol column C106 which is operated at a pressure from about 3 to 7 atmospheres. Azeotroping agent is fed near the top of column C106 via stream 23 which is produce in drying column C107. CBM or azeotropic isopropyl alcohol at 87 wt% is withdrawn from upper part of alcohol column via stream 24 as a product while water is withdrawn from bottom of column via stream 25.
11. In drying column C107, which is operated at a pressure of 14.7 psi and a temperature of 347 K, ternary azeotrope is formed. The latter concentrates at the head of column in a concentration of about 60%, is piped via stream 26 into condenser, so that after liquefaction of the vapots in condenser, it enter decanter F101 via stream 27 to separate the layers into a virtually water-free upper layer and lower layer containing the residual water. The upper layers in this tank which is mainly azeotroping agent and alcohol, is return to the top of the column C107 as reflux via stream 28. While anhydrous isopropyl alcohol at 99.8 wt% is removed from the lower part of column C107 via stream 29.
12.The lower layer in the decanter is mostly water. It is fed into stripping column C108 which is operated at a temperature 466K and a pressure 155 psi via stream 30 for recovery of isopropyl alcohol and azeotroping agent. This product is send back into column C107 via stream 31 and waste the water at stream 32.
CONCLUSION
Isopropyl alcohol is a flammable, colorless liquid with a slightly pleasant odor. It is used in manufacturing acetone, glycerol and isopropyl acetate. A solvent for many oils, alkaloids, gums and resins, it also serves as a deicing agent for liquid fuels. The chemical compound is used in extraction processes, as a dehydrating agent, a preservative, in lotions and as a laboratory reagent. Common names for it include IPA, rubbing alcohol, dimethyl carbinol, isopropanol, 2-propanol and sec-propyl alcohol. The indirect process reacts propene with sulfuric acid to form a mixture of sulfate esters. Subsequent hydrolysis of these esters produces isopropyl alcohol. Direct hydration reacts propene and water, either in gas or liquid phases, at high pressures in the presence of solid or supported acidic catalysts. IPA is used in the extraction and purification of natural products such as vegetable and animal oil and fats. Other applications include its use as a cleaning and drying agent in the manufacture of electronic parts and metals, and as an aerosol solvent in medical and veterinary products. It can also be used as a coolant in beer manufacture, a coupling agent, a polymerization modifier, a de-icing agent and a preservative. Use of IPA in direct solvent applications accounted for 62% of total IPA demand in 2008. IPA is also used in surface coatings, inks, pesticide formulations, electronic applications, reagents and as a processing solvent in the production of resins. Global IPA-based acetone production is expected to decrease with the increase of phenol capacity (acetone is a coproduct of phenol by the cumene peroxidation process). It is estimated that IPA-based acetone will no longer be produced in Western Europe after 2010. Worldwide IPA consumption is forecast to grow at an average annual rate of 1.0 – 1.5% during 2008 – 2013. In 2008, global supply/demand was relatively balanced as demand decreased because of the weakened global economy. As of late 2008/early 2009, the acetone market has been tight as a result of its co product phenol’s decreased demand (and hence production).
This could lead to increased IPA consumption for competing applications, particularly chemical intermediates. Supply/demand and feedstock (propylene) costs have had and will continue to have the greatest effect on IPA pricing. The future demand of IPA is expected to remain flat or to grow slightly. Its main usage as a chemical intermediate is growing, and this should offset the pressure on use as a solvent from tighter volatile organic chemicals (VOC) regulations.
REFERENCES
1. Anis Bt. Jaafar. (1992). Loji Penghasilan Isopropil Alkohol. Fakulti Kejuruteraan, Universiti Kebangsaan Malaysia. 2. Paul E. Burton. (1984). Process for Producing Isopropyl Alcohol and Di-isopropyl Ether. United States Patent Number 4471142. 3. Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 4. Robert H. Perry. (1997). Perry’s Chemical Engineer’s Handbook. McGraw Hill, 7 th Edition 5. Isopropyl alcohol from Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Isopropyl_alcohol 6. What is Isopropyl Alcohol? http://www.wisegeek.com/what-is-isopropyl-alcohol.htm 7. Isopropanol general information. http://chemicalland21.com/petrochemical/isopropanol.htm 8. Material Safety Data of Isopropyl Alcohol. http://kinetronics.com/PLCMSDSData.pdf 9. Occupational Safety and Health Guideline for Isopropyl Alcohol http://www.osha.gov/SLTC/healthguidelines/isopropylalcohol/recognition.html
