I menghasilkan hipertiroid yang kontiniu dan membutuhkan terapi ulang dan pembedahan untuk mengangkat kelenjar tiroid.
Referensi
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Abraham-Nordling M, Törring O, Lantz M, et al. Incidence of hyperthyroidism in Stockholm, Sweden, 2003-2005. Eur J Endocrinol . Jun 2008;158(6):823-7.
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Gabriel EM, Bergert ER, Grant CS, et al. Germline polymorphism of codon 727 of human thyroidstimulating hormone receptor is associated with toxic multinodular goiter. J Clin Endocrinol Metab. Sep 1999;84(9):3328-35.
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