16/12/2557
2 HAU L43 | How to M ake M etham phetam i ne
Let’s Make Meth
This is a one-step procedure l-(-)-ephedrine hydrochloride ————–> methamphetamine hydrochloride(methyl alpha-methyl phenyl ethyl amine) by means of HI/ red P. d-(+)-Pseudoephedrine hydrochloride can substitute. The d-(+) enantiomer results. That is the one with the configuration (S) at the assymetric carbon. 1. Putting everything in the flask. 2. Heating slowly since the reaction bumps when it kicks in. Reflux, it will be 130 degrees C. 3. Wait 20 hours. It is either more or less time if there is more of the chemicals. I don’t remember. I think more. 4. Let cool. 5. Filter using a water aspirator, secured-down large Buchner funnel, filter flask. Get all the phosphorous out. By secured I mean that if you use a ring stand, make sure a Buchner full of water on it will not tip over. Use a brick on the base if necessary, and it will be. Also secured is the filter paper fitting the Buchner. It has to be the correct diameter. Start the aspirator pump vacuum by turning on your faucet, then hit the paper in the funnel with a stream of water from a wash bottle. The paper should wet and stick down like a wet t-shirt. Then pour in the nasty hot shit. when it is filtered save the filtrand (solid). Place it wet in a closed jar. It is phosphorous and subject to catch fire. Actually, take a look at these items of commerce: HI, 57 % one gallon (3785 milliliters) $280 ephedrine HCl, 1 kg $400 red phosphorous 1 lb (454.4 g) $50 See, that’s enough HI for one run in a 12-L flask, enough E for two runs, and enough P for nine runs. On price, you’d throw it away. I threw it away. Why get busted with it? Used P is a slam-dunk for evidentiary gold. It is different now, therefore ppl are hot on saving it. They all say that. As different as it is, the expediency of a gassing step, a freon step, are a little less attractive than a hydriodic acid recovery step (distilled out after the reaction. If you neutralize it, it is gone), or a hydriodic acid manufacturing step, rather than generating HI in situ. 6. Filtered of P, the yellow reaction mixture is tested for completion of the reaction. 7. The rxn mixture is returned to the flask, or put in a flask twice as big, with a large glass funnel. 8. A premixed 50% NaOH in water solution, which is cool, with ice cubes even, is added slowly with gloves and goggles on. Don’t sniff the methanimus vapor. This reacts vigorously. Base it over, or overbase it, until there is a layer of oil on top, and the pH tests out to “above 10″ on test paper. Take your sample from the bottom (water) layer, using a homemade micropippette. 9. Set it up for downward distillation. Use a boiler and steam distill into a separatory funnel until the drops are no longer two-phase; until the distillate tests as water. 10. Neutralize a portion of the oil layer to 7.0 (phenol red) with conc. HCL, reagent grade. Leave undisturbed overnight for crystals to form. 11. Swirl crystals loose in solution and send them into a fritted glass funnel. Suck but don’t suck air through them. Rinse with minimal acetone. Flamedraw the tip on the red acetone wash bottle. Snip it off to the half-millimeter diam. with scissors. Place funnel in Pyrex casserole dish and let dry without data:te data:text/html;charset=utf-8,%3Cp xt/html;charset=utf-8,%3Cp%20style%3 %20style%3D%22fo D%22font-size%3A%20 nt-size%3A%201.0 1.05e 5em%3B%20 m%3B%20color%3A%20 color%3A%20rgb(51%2 rgb(51%2C%205 C%2051%2C%2 1%2C%2051 051)%3B%20 )%3B%20fon font-famil t-famil y…
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16/12/2557
2 HAU L43 | How to Make Methamphetamine
heat lamp. It will melt them. Examine crystals with hand lens. They should have sharp edges, no dust, nor hairs, nor perfume. That is, do not have any air freshener present in the kitchen. 12. Do not use a microwave or clothes dryer for anything. Do not attempt to use brain power to overcome the lack of anything. Org Syn Coll Vol. I p 224-5 (to see if there’s a clue about how to add ingredients when iodine is being used, to avoid the sudden pressure developed) DIPHENYLACETIC ACID
(C6H5)2C(OH)CO2H + 2(H) –> (C6H5)2CHCO2H + H2O 1. Procedure In a 1-l. round-bottomed flask are placed 250 cc. of glacial acetic acid, 15 g. of red phosphorus, and 5 g. of iodine. The mixture is allowed to stand for fifteen to twenty minutes until the iodine has reacted, and then 5 cc. of water (Note 1) and 100 g. (0.44 mole) of benzilic acid are added. A reflux condenser is attached, and the mixture is boiled continuously for at least two and one-half hours. After the reaction is complete, the hot mixture is filtered with suction to remove the excess red phosphorus (Note 2). The hot filtrate is slowly poured into a cold, well-stirred, filtered solution of 20-25 g. of sodium bisulfite in 1 l. of water (Note 3). This procedure removes the excess iodine and precipitates the diphenylacetic acid as a fine white or slightly yellow powder. 2. Notes 1. In place of phosphorus, iodine, and water, a dilute solution of hydriodic acid and phosphorus may be used. 2. If difficulties are encountered in filtring the hot acetic acid solution through filter paper, an asbestos filter may be prepared and used to advantage. 3. Some samples of sodium bisulfite caused part of the diphenylacetic acid to dissolve. This can always be avoided if, after the solution of sodium isulfite is prepared, a current of sulfur dioxide is passed in, until the solution is acid to litmus. 3. Methods of Preparation Diphenylacetic acid can be prepared by the reduction of benzilic acid with hydriodic acid and red phosphorus (1), by carbonation of the reaction product of phenylsodium and diphenylmethane, and by hydrolysis of 1,1dichloro-2,2-diphenylethylene. 1. Jena, Ann. 155, 84 (1870); Klingemann, Ann. 275, 84 (1893); Zinssen, Ber. 24, 3556 (1891); Chichibabin, Ber. 44, 442 (1911). Those two journals are called “Annalen”, and “Berichte”. That is the first word in each title. Go ahead and sound it out if it is not in English. They know what you are doing, so they make it easy.
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