54891754 Pathophysiology Acute Gastroenteritis AGE

PATHOPHYSIOLOGY A C U T E G A S T R OE N T E R IT I S

PREDISPOSING FACTORS Extreme ages Immunocompromised Immune deficiency disease

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PRECIPITATING FACTORS Poor sanitation Contaminated food and water Poor food preparation 

Etiology: bacterial/viral bacterial/viral

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Ingestion of contaminated food/water 

Pathogen enters Gastrointestinal tract

Interrupted normal intestinal flora activity

Pathogen release endotoxins

Stimulation of mucosal lining of intestine

Invation and destruction of mucosal lining of intestine

Increased secretion of water and electrolytes into intestinal lumen

Increased secretion of chloride and bicarbonate ions

Irritation of intestinal mucosa

bleeding

ulceration

hematochezia Inhibition of sodium reabsorption Altered digestion and reabsorption

Abdominal pain

Indigestion of food

Increased secretion of protein-rich fluid

Inhibition ofprotein-rich fluid reabsorption

diarrhea

Watery stool

Los of f luids and electrolytes

dehydration

Dry skin

Poor skin turgor

Abdominal distension

Abdominal cramping

nausea

Abdominal pain

Excessive release of gas

vomiting

Excessive borborygmi

Increased secretion of proteinrich fluid in bowel