Medical-Surgical Nursing Endocrine System Reviewer Endocrine system 1. 2. 3. 4. 5. hormones released into the bloodstream travel throughout the body target is usually far from site of synt…Full description
Endocrine nursing notes f you have questions please email me> [email protected]
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Endocrine [MEN SYNDROMES] This is for those going for the gold. I include it because it was my first patient in residency. It was also likely my last encounter with it. MEN1 Syndrome Also known as Wermer’s Syndrome, this is an autosomal dominant mutation of MEN1 gene that causes hyperplasia or adenomas of the “3 Ps:” Pituitary Adenomas, Parathyroid Adenomas, and Pancreatic Adenomas. There’s a strong association with Gastric Ulcers (Zollinger-Ellison syndrome from the pancreatic adenomas), Hypoglycemia (Insulinoma), and Hypercalcemia (PTH). MEN2A and MEN2B These are essentially the same disease and aren’t clearly separated. Both are caused by a mutation in the RET protooncogene. They cause endocrine tumors everywhere except the 3ps. Look for Pheochromocytomas and thyroid adenomas. The parathyroid gland can also be involved, but isn’t classic. Really, the only difference between 2A and 2B is the presence of neuronal tumors found in MEN2B. MEN1 = Pituitary + Pancreas + Parathyroid MEN2A = Pheochromocytomas + Thyroid + Parathyroid MEN2B = Pheochromocytomas + Thyroid + Neuronal Real life vs test This is rare (~1 in 50,000) – you’re not going to see it. If there’s a combination of: - recurrent endocrine neoplasias + - age <40 + - family history + - multiple organ systems affected You’d suspect something was up and do a mutational analysis of the MEN1/2 genes.
