Bio3200: Human Physiology 3 credits MW3-4:20pm Gen Lectures 100 Mark F.A. VanBerkum anBerkum 5178 Biological Sciences Building 577-5554
[email protected]
F2010
Description and Objective: To understand the basic principles of human physiology. physiology. Major organ systems systems will be covered emphasizing emphasizing the structure and function AND regulation = PHYSIOLOGY Basic cell biology & biochemistry very helpful – reviewed in first few chapters. Represent baseline knowledge you are expected to have via prer equisites = Bio1510/2600.
Bio3070*
Bio1510 Bio2600 Bio3100* Bio32000
Description and Objective: To understand the basic principles of human physiology. physiology. Major organ systems systems will be covered emphasizing emphasizing the structure and function AND regulation = PHYSIOLOGY Basic cell biology & biochemistry very helpful – reviewed in first few chapters. Represent baseline knowledge you are expected to have via prer equisites = Bio1510/2600.
Bio3070*
Bio1510 Bio2600 Bio3100* Bio32000
Text:
The text is REQUIRED reading. students are responsible for ALL for ALL material even if NOT specifically covered in class. The text chosen is: Human Physiology: An Integrated Approach with Interactive Physiology, Fifth Edition by Dee Unglaub Silverthorn [IBSN: 0321559398]. Fourth edition: Ok I think – BUT no guarantee
Communication: Office hours:
M & W: 1:30 to 2:30 pm T 1-2 pm [ but NOT always] You may also e-mail for a mutually convenient appointment. answer only an ODD question or two via e-mail; if complicated find me I do NOT reply to notes repeating announcements or found on BB Class Web Site: Go to Pipeline and Blackboard [http://blackboard.wayne.edu/] to access the class web site for most class handouts (syllabus, lecture notes etc), which will be available as PDF files. CHECK this site often, as I will try to upload a PDF file of my PowerPoint slides before each class. I also anticipate using an overhead or tablet so come prepared to take notes.
Attendance: Class attendance is mandatory for an exam day (see dates below): failure to write an exam results in a zero (0). I strongly recommend that you attend all classes to augment your own reading of the text and to catch a glimpse of how I think/emphasize selected topics. Timeliness: On exams dates do NOT arrive late!! You will not be allowed to take the exam if you arrive after the first student has finished the exam and left the room (and some students finish in less than 15 min). Assuming you sit for the exam, no additional time will be provided. Religious Conflicts: Tell me NOW – i.e. by Sept. 8, 2010 i.e. look at ALL exam dates now. No make-up exams will be given unless you have notified me in writing by the above date. ADD/DROP POLICY: I follow all university policies on adding or dropping this class. Contact Mrs. Hunter, Biology Advisor for help in this area.
Individuals with Disabilities: Register with Student Disability Services (SDS) for coordination of your academic accommodations, then co-ordinate with me. UNEXPECTED UNIVERSITY CLOSURES: will hear via: 1. the University Newsline (313) 577-5345 * 2. WSU Homepage (www.wayne.edu) * 3. WSU Pipeline (www.pipeline.wayne.edu) * 4. WDET-FM (Public Radio 101.9) 5. by other local radio and television stations If the University is officially closed on an exam day, the exam will be held on the next regularly scheduled class day. Any specific issue not covered by this syllabus will be resolved using University policies. Disputes that cannot be resolved following the guidelines present in this syllabus will be resolved by following the guidelines of the University “Student Due Process”.
GRADING: 4 class exams, and a cumulative final exam. Plus 25 ‘bonus’ clicker points EXAM DATES: will NOT change, content may NO MAKE-UP EXAMS will be given as you drop lowest, if don’t write = zero multiple choice with problem solving and reasoning. Old exams on Blackboard, NOT section 3 The FINAL Exam is CUMULATIVE, worth 200 points
EXAM DATES:
Wed. Sept. 22, 2010 Mon. Oct. 18, 2010 Wed. Nov. 10, 2010 Mon. Dec. 6, 2010 Final:
FRIDAY Dec. 17, 2010 AT 1:20 pm
scheduled FRIDAY Dec. 17 starting at 1:20 am (NOTE TIME AND DAY). DO NOT be late, as no extra time is provided. Make-up exam: REQUIRE documented reason (e.g. illness, or family emergency) signed by a non-family professional person (e.g. doctor, police officer, funeral director etc.): travel plans will NOT be used as a reason to take a make up. Without a note you do NOT write a make up AND you get a zero a make-up exam may not occur until January.
Grade Calculation: A letter grade is calculated after total score normalized (averaged) to the score of the second highest student. This number converted to percentage and assigned a letter grade according to the table at right.
Exam I Exam II Exam III Exam IV Final Ex
100 points 100 points 100 points 100 points
top 3 scores = 300 points
= 200 points TOTAL = 500 points + clicker bonus points 25
93-100% 90-92 86-89 82-85 80-81 76-79 72-75 70-71 67-69 63-66 60-62 59 or less
A AB+ B BC+ C CD+ D DF
Clicker Bonus Points: starts for points AFTER Exam 1 (although Qs will be used sooner) 25 points for voluntary/optional use added to exam scores if answer 90% of all questions asked = 25 points, prorated accordingly ONLY accept answers received by my computer because you are here. If I see multiple clickers in use – all will be confiscated – and returned to students during office hours – ALL students involved will LOSE any chance for bonus points and any funds spent on getting them.
Questions?
Physiology = INTEGRATION & Homeostasis between body systems
Internal and External environments.
It is ALL about homeostasis
Input Signal
Controller
Output Signal
Figure 1-4
Concept Mapping = Flow Charts allows you to create a basic structure that lets you “hang” the details onto
Figure 1-5b
Read & understand the section on graphs and how to “read” them (i.e. convert them into a sentence describing the relationship between dependent and independent variables -- the text is full of them! Table 1-2
Cell Communication: Recap from 2600 Signal Transduction - conversion of one type of signal to another ions
+ a fifth one - “autocrine” -self-regulation, feedback to self
Figure 6-2 - Overview
Figure 6-1 - Overview
Signal transduction: conversion of an extracellular signal to intracellular signal ligand
2600:
In Bio2600: we used concept of
hydrophilic (= lipophobic) vs
hydrophobic (= lipophilic)
Figure 6-4 (2 of 3)
general types of membrane receptors:
Figure 6-5
2600
review Protein Kinase A and C cascades
Figure 6-6
Ligand-Receptor interaction: key communication step KINETICS: degrees of specificity saturation maximum conductance rate
regulated (gated) inhibitable (biologically &/or
pharmacologically)
Agonist and Antagonists
see pgs. 40-45 for review on protein interactions and kinetics
Tyrosine kinase signaling
Figure 6-10
Homeostasis: maintain a relatively stable environment need to detect environment, assess if OK from either direction, and have mechanism to fix = variety of CONTROL SYSTEMS Canon’s Postulates: 1. nervous system plays role in organism fitness 2. tonic control is often used - set at a mid-point so can go UP & DOWN
3. Antagonistic control -- positive and negative feedback loops regulate activity 4. ligand and receptor specificity endocrine – one hormone, many receptors = differential response Figure 6-19
Control mechanism – two phases: Response loop: Afferent
and
integration center
Feedback loop: Efferent
Figure 6-23
tonic control of blood vessel diameter
Antagonist control of heart rate
Homeostasis: Multiple levels of control LOCAL vs Reflex control:
Figure 6-22
means body must “integrate” information and often it oscillates near a set point but not exactly on it as you get feedback fromboth sides of the set point. (over shoot/ undershoot)
Figure 6-26
Control systems • vary in specificity, speed and duration • simple to complex, • mixed endocrine & neuronal loops • every connection point is an integration point (i.e. cell has to make a decision to do something or not)
