ACE Inhibitor Side Effects CAPTOPRIL C ough A naphylaxis
ACE Inhibitor Side Effects 4H yperkalemia, hypertension, gum hypertrophy, hair R enal toxicity T remor
P alpitations
Gynacomastia Causing Drugs
T aste
DISCO MTV
O rthostatic hypotension
D igoxin
P otassium elevated
I soniazid
R enal impairment
S pironolactone
I mpotence
C imetidine
L eukocytosis
O estrogens
Anti-Epileptic Side Effect
M ethyldopa/metronidazole
ABCDEFGH A taxia
T CAD V erapamil
B lood dyscrasia
MAOI Side Effects
C left lip
The 3Hs
D upuytrens / Vit D deficiency
H epatocellular jaundice
E xfoliation of skin & Stevens Johnson's
H yperthermia
F its
H ypertension
G I upset/gum hypertrophy
Propranolol, contra-indications
H epatitis/hairy
ABCDE
Barbiturate Side Effects
A sthman
ABCD
B lock (heart)
A taxia
C ardiac failure
B ehavioral disturbance
D M (hypoglycemic shock)
C oncentration decreased/coma
E xtremities (occlusive arterial disease)
D epression/drowsy/diplopia
Pulmonary Edema, Non-Cardiac
Cholinergic OD Side Effects
PONS
DUMB BELS
P hosgene/paraquat/phenothiazines
D iarrhea
O pioids/organophosphates
U rination
N itrous dioxide
M iosis/muscle weakness
S alicylate
B ronchorrea
TCAD Side Effects
B radycardia E mesis L acrimation S alivation/sweating
CAN WOO C VS A nticholinergic N euro
Cyclosporin Side Effects
W ithdrawal
4HRT
O verdose
ACE Inhibitor Side Effects
ACE Inhibitor Side Effects
O thers
I nfection
Rat Poison
G lycosuria
RATS PANIC R ed squill A rsenic
O besity/osteoporosis/oedema I mmunosuppression/insomnia D epression
T hallium
Warfarin
S trychnine
WEPT
P NU/phosphorus/ZN phosphide
W arfarin
A lpha naphtha thiurea (ANTU)
E xtrinsic pathway
N orbormide
Measure PT
I ndanediones
Class IC Antiarrhythmics
C oumarin/cholecalciferol
FEP
Steroid Side Effects
F lecainide
HIGH COMPACT IMPS
E ncainide
H ypertension
P ropafenone
I mmunosuppresion
Class III Antiarrhythmics
G astric ulcer (bleeding) H eartburn C ataract O steoporosis M uscle weakness
SIBA S otalol I butilide B retylium A miodarone Beta 1 Selective Blockers
P ath #/psychosis
A-BEAM
A cne/altered glucose
A cebutalol
C ushingoid
B etaxolol
T hin skin
E smolol
I ncreased appetite
A tenolol
M yopathy
M etoprolol
P oor wound healing
Gynacomastia, Drugs That Cause
S tress response reduced
"Some Drugs Create Awesome Knockers
or
S pironolactone
AM CUSHINGOID
D igistalis
A cne
C isplatin
M yopathy/proximal muscle weakness
A lcohol
C ushingoid/cataract
K etoconozole
U lcers S triae, skin thinning/bruising H ypertension/hairy
Drugs Causing Pulmonary Fibrosis BABE B leomycin
ACE Inhibitor Side Effects A miodarone B usulfan E (empty)
ACE Inhibitor Side Effects TOM thumb T riazolam O xazepam
Drugs that Cause Hepatic Necrosis
M idazolam
HAVE
Beta 2 Agonists
H alothane A cetaminophen (liquefactive necrosis) V alproic acid E (empty)
SMART S almeterol M etaproterenol A lbuterol
Drugs Causing Agranulocytosis
R itodrine
The 3Cs
T erbutaline
C lozapine
Stevens-Johnson Syndrome
C olchicine C arbamazepine
LESS L amotrigine
Drugs for All Types of Seizures (except petit mal)
E thosuximide
CAPHE
S ulfonamides
CA rbamazepine
S tevens-Johnson
PHE nytoin/phenobarbital
Fluconazole
Drugs for Petit Mal Seizures
The 3Cs
VALET
C andidiasis
VAL proic acid
C occidiomycosis
ET hosuximide
C ryptocococcal meningitis
Vancomycin
Class IB Antiarrhythmics
"A Red Van Drove Into The Wall"
"Medical Lab Technician"
A ntihistamines (prevents redman syndrome)
M exilietine
R ed man syndrome
L idocaine
V ancomycin
T ocainide
D -ala D-ala
Lithium
I nhibitor T hrombophlebitis W all (as in cell wall)
LITHIUM L eukocytosis I nhibits PIP2, cAMP and 5' deiodinase
Tuberculosis Drugs
T eratogenic/thiazide contraindicated
RESPI
H ypothyroidism/hyponatremia increases toxicity
R ifampin
I nsipidus (nephrogenic diabetes)
E thambutol
visUal dysfunction
S treptomycin
M ovement disorders: CATS (choreoathetosis, ataxia, tremors, seizures)
Pyrazinamide I soniazid Short Acting Benzodiazepines
Drugs Contraindicated During Pregnancy SAFE CT
ACE Inhibitor Side Effects
ACE Inhibitor Side Effects
S ulfonamide
P hlebitis
A minoglycoside
H eadaches/hypotension/hypokalemia
F louroquinolones
T hrombocytopenia
E rythromycin
E mesis, encephalopathy
C larithromycin
R espiratory strida
T etracycline
I ncreased temperature (fever)
Benzodiazepines Metabolized Outside the Liver
C hills
"Outside The Liver O xazepam T emazepam
I mmediate hypersensitivity (anaphylaxis) N ephrotoxicity--important! B ronchospasm
L orazepam
CNS Effects of Morphine
Drugs Cuasing Megaloblastic Anemia
SCREAMNT
MAPLE M ethotrexate A ZT = zidovudine P henytoin (causes folate deficiency) L iver disease E thanol Amphotericin Toxicities AMPHOTERICIN B A nemia
S edation C ough suppression/convulsions R espiratory depression E uphoria A nalgesia M yosis (but may cause mydriasis in doses causing asphyxia) N ausea and vomiting T runcal rigidity (especially with fentanyl)
M uscle spasms
HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions HMG-CoA: · Side effects: Hepatotoxicity Myositis [aka rhabdomyolysis] · Contraindications: Girl during pregnancy/ Growing children · Interactions: Coumarin/ Cyclosporine Antiarrhythmics: class III members BIAS: Bretylium Ibutilide Amiodarone Sotalol Ca++ channel blockers: uses CA++ MASH: Cerebral vasospasm/ CHF Angina Migranes Atrial flutter, fibrillation Supraventricular tachycardia CHASM
Cererbral vasospasm / CHF Hypertension Angina Suprventricular tachyarrhythmia Migranes Antiarrhythmics: classification I to IV MBA College· In order of class I to IV: Membrane stabilizers (class I) Beta blockers Action potential widening agents Calcium channel blockers Anticholinergic side effects "Know the ABCD'S of anticholinergic side effects": Anorexia Blurry vision Constipation/ Confusion Dry Mouth Sedation/ Stasis of urine Antimuscarinics: members, action "Inhibits Parasympathetic And Sweat": Ipratropium Pirenzepine Atropine Scopolamine _Muscarinic receptors at all parasympathetic endings sweat glands in sympathetic. Aspirin: side effects ASPIRIN: Asthma Salicyalism Peptic ulcer disease/ Phosphorylation-oxidation uncoupling/ PPH/ Platelet disaggregation/ Premature closure of PDA Intestinal blood loss Reye's syndrome Idiosyncracy Noise (tinnitus) Benzodiazapines: ones not metabolized by the liver (safe to use in liver failure) LOT: Lorazepam Oxazepam Temazepam Benzodiazepenes: antidote "Ben is off with the flu": Benzodiazepine effects off with Flumazenil. Benzodiazepenes: drugs which decrease their metabolism "I'm Overly Calm": Isoniazid Oral contraceptive pills Cimetidine _ These drugs increase calming effect of BZDs by retarding metabolism. Benzodiazepines: actions "Ben SCAMs Pam into seduction not by brain but by muscle": Sedation anti-Convulsant anti-Anxiety Muscle relaxant Not by brain: No antipsychotic activity. Beta selective blockers "BEAM ONE up, Scotty": Beta blockers:
Esmolol Atenolol Metropolol Botulism toxin: action, related bungarotoxin Action: "Botulism Bottles up the Ach so it can't be the released": Related bungarotoxin: "Botulism is related to Beta Bungarotoxin (beta-, not alpha-bungarotoxin--alpha has different mechanism). Cholinergics (eg organophosphates): effects If you know these, you will be "LESS DUMB": or SLUDGE Lacrimation Excitation of nicotinic synapses Salivation Sweating Diarrhea Urination Micturition Bronchoconstriction Delerium-causing drugs ACUTE CHANGE IN MS: Antibiotics (biaxin, penicillin, ciprofloxacin) Cardiac drugs (digoxin, lidocaine) Urinary incontinence drugs (anticholinergics) Theophylline Ethanol Corticosteroids H blockers Antiparkinsonian drugs Narcotics (esp. mepridine) Geriatric psychiatric drugs ENT drugs Insomnia drugs NSAIDs (eg indomethacin, naproxin) Muscle relaxants Seizure medicines Direct sympathomimetic catecholamines DINED: Dopamine Isoproterenol Norepinephrine Epinephrine Dobutamine Inhalation anesthetics SHINE: Sevoflurane Halothane Isoflurane Nitrous oxide Enflurane _ If want the defunct Methoxyflurane too, make it MoonSHINE. Ipratropium: action Atropine is buried in the middle: iprAtropium, so it behaves like Atropine. Lead poisoning: presentation ABCDEFG:
Anemia Basophilic stripping Colicky pain Diarrhea Encephalopathy Foot drop Gum (lead line) Lithium: side effects LITH: Leukocytosis Insipidus [diabetes insipidus, tied to polyuria] Tremor/ Teratogenesis Hypothyroidism MAOIs: indications MAOI'S: Melancholic [classic name for atypical depression] Anxiety Obesity disorders [anorexia, bulemia] Imagined illnesses [hypochondria] Social phobias _ Listed in decreasing order of importance. _ Note MAOI is inside MelAnchOlIc. Methyldopa: side effects METHYLDOPA: Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia (haemolytic) Monoamine oxidase inhibitors: members "PIT of despair": Phenelzine Isocarboxazid Tranylcypromine _ A pit of despair, since MAOs treat depression. Morphine: effects MORPHINES: Miosis Orthostatic hypotension Respiratory depression Pain supression Histamine release/ Hormonal alterations Increased ICT Nausea Euphoria Sedation Morphine: effects at mu receptor PEAR: Physical dependence Euphoria Analgesia Respiratory depression Narcotic antagonists The Narcotic Antagonists are NAloxone and NAltrexone. _ Important clinically to treat narcotic overdose. Parkinsonism: drugs
SALAD: Selegiline Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine) L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide) Amantadine Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide) Phenytoin: adverse effects PHENYTOIN: P- interactions Hirsutism Enlarged gums Nystagmus Yellow-browning of skin Teratogenicity Osteomalacia Interference with B metabolism (hence anemia) Neuropathies: vertigo, ataxia, headache Physostigmine vs. neostigmine LMNOP: Lipid soluble Miotic Natural Orally absorbed well Physostigmine _ Neostigmine, on the contrary, is: Water soluble Used in myesthenia gravis Synthetic Poor oral absorption Pupils in overdose: morphine vs. amphetamine "MorPHINE: Fine. AmPHETamine: Fat": Morphine overdose: pupils constricted (fine). Amphetamine overdose: pupils dilated (fat). Serotonin syndrome: components Causes HARM: Hyperthermia Autonomic instability (delirium) Rigidity Myoclonus Sodium valproate: side effects VALPROATE: Vomiting Alopecia Liver toxicity Pancreatitis/ Pancytopenia Retention of fats (weight gain) Oedema (peripheral oedema) Appetite increase Tremor Enzyme inducer (liver) Succinylcholine: action, use Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore. You Suck stuff in through a mouth-tube, and drug is used for intubation. Tricyclic antidepressants: members worth knowing "I have to hide, the CIA is after me": Clomipramine Imipramine Amitrptyline _ If want the next worth knowing, the DNDis also after me: Desipramine Norrtriptyline
Doxepin Tricyclic antidipressents (TCA): side effects TCA'S: ThrombocytopeniaCardiac (arrhymia, MI, stroke) Anticholinergic (tachycardia, urinary retention, etc) Seizures Vigabatrin: mechanism Vi-GABA-Tr-In: Via GABA Transferase Inhibition Antibiotics contraindicated during pregnancy MCAT: Metronidazole Chloramphenicol Aminoglycoside Tetracycline Busulfan: features ABCDEF: Alkylating agent Bone marrow suppression s/e CML indication Dark skin (hyperpigmentation) s/e Endrocrine insufficiency (adrenal) s/e Fibrosis (pulmonary) s/e Metabolism enzyme inducers "Randy's Black Car Goes Putt Putt and Smokes": Rifampin Barbiturates Carbamazepine Grisoefulvin Phenytoin Phenobarb Smoking cigarettes Morphine: side-effects MORPHINE: Myosis Out of it (sedation) Respiratory depression Pneumonia (aspiration) Hypotension Infrequency (constipation, urinary retention) Nausea Emesis Therapeutic index: formula TILE: Code: TI = LD / ED Zero order kinetics drugs (most common ones) "PEAZ (sounds like pees) out a constant amount": Phenytoin Ethanol Aspirin Zero order _ Someone that pees out a constant amount describes zero order kinetics (always the same amount out) Asthma drugs: leukotriene inhibitor action zAfirlukast: Antagonist of lipoxygenase zIlueton: Inhibitor of LT receptor Beta- vs Beta- receptor location "You have heart and lungs": Beta- are therefore primarily on heart. Beta- primarily on lungs. Hepatic necrosis: drugs causing focal to massive necrosis
"Very Angry Hepatocytes": Valproic acid Acetaminophen Halothane Adrenoceptors: vasomotor function of alpha vs. beta ABCD: Alpha = Constrict. Beta = Dilate. Beta blockers with intrinsic sympathomimetic activity Picture diabetic and asthmatic kids riding away on a cart that rolls on pinwheels. Pindolol and Carteolol have high and moderate ISA respectively, making them acceptable for use in some diabetics or asthmatics despite the fact that they are non-seletive beta blockers. Beta-blockers: main contraindications, cautions ABCDE: Asthma Block (heart block) COPD Diabetes mellitus Electrolyte (hyperkalemia) Beta-blockers: nonselective beta-blockers "Tim Pinches His Nasal Problem" (because he has a runny nose...): Timolol Pindolol Hismolol Naldolol Propranolol 1.Succinylcholine: action, use Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore. You Suck stuff in through a mouth-tube, and drug is used for intubation 2.Cholinergics (eg organophosphates): effects If you know these, you will be "LESS DUMB": Lacrimation Excitation of nicotinic synapses Salivation Sweating Diarrhea Urination Micturition Bronchoconstriction 3.Steroids: side effects BECLOMETHASONE: Buffalo hump Easy bruising Cataracts Larger appetite Obesity Moonface Euphoria Thin arms & legs Hypertension/ Hyperglycaemia Avascular necrosis of femoral head Skin thinning Osteoporosis Negative nitrogen balance Emotional liability 4.Methyldopa: side effects METHYLDOPA: Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity
psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia (haemolytic) 5.Sodium valproate: side effects VALPROATE: Vomiting Alopecia Liver toxicity Pancreatitis/ Pancytopenia Retention of fats (weight gain) Oedema (peripheral oedema) Appetite increase Tremor Enzyme inducer (liver) 6. Captopril (an ACE inhibitor): side effects CAPTOPRIL: Cough Angioedema/ Agranulocystosis Proteinuria/ Potassium excess Taste changes Orthostatic hypotension Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension) Renal failure (and renal artery stenosis contraindication)/ Rash Indomethacin inhibition Leukopenia/ Liver toxicity 7.Lithium: side effects LITH: Leukocytosis Insipidus [diabetes insipidus, tied to polyuria] Tremor/ Teratogenesis Hypothyroidism 8.Opioids: effects BAD AMERICANS: Bradycardia & hypotension Anorexia Diminished pupilary size Analgesics Miosis Euphoria Respiratory depression Increased smooth muscle activity (biliary tract constriction) Constipation Ameliorate cough reflex Nausea and vomiting Sedations 9.Ca++ channel blockers: uses CA++ MASH: Cerebral vasospasm/ CHF Angina Migranes Atrial flutter, fibrillation Supraventricular tachycardia Hypertension · Alternatively: "CHASM": Cererbral vasospasm / CHF Hypertension
Angina Suprventricular tachyarrhythmia Migranes
