FORMULASI “ANTI DIARE”
OLEH : KELAS
:C
KELOMPOK
: IV
ASISTEN
:
NO
NAMA
1
MUHAMMAD TAKDIR B.
2
AYU RIA ANDRIANI
3
RIRIN ANDRIANI
4
NIM
WA ODE HASNIAR
JURUSAN FARMASI FAKULTAS FARMASI UNIVERSITAS UNIVERSITAS HALU OLEO KENDARI 2016
TT
FORMULASI “ANTI DIARE” A. FORMULA ASLI R/ Zink !"#$% B. RAN&AN'AN FORMULA Ti$( 2)) *+ %$,"-% *-n+$n!n+ 1. Zink !"#$%..................... 20 *+ 2. .............................. 0 3. L$k%$....................$ 1))
A. MASTER FORMULA 1. N$*$ 5!k 2. 7!*"$8 5!k 3. T$n++$" F5*$"i$ 4. T$n++$" 5!ki 0. N.5-+i%5$i 9. N.,$%;8
DIAZIN6 1)) 24 7UNI 2)19 24 A'USTUS 2)1: DBL19))1))110A1
Di,!$% "-8 T< Yn%$ M$5i$ N K- B$8$n N$*$ B$8$n . 1 2 3 4
1
1 > ZN 2 > 3? LK 4?MK
Zink !"#$% L$k%$ M-%i"-"!"$
Di-%!=!i "-8 F!n+i -5 i Z$% $k%i# Diin%-+5$n (-+ii -n@$"!%
-5 ,$%;8
*+
ALASAN EMILIHAN KADAR ZAT AKTIF M-n!5!% ,$=$i% $n =$@ i Zink i+!n$k$n !n%!k 5$" !n%!k ,$"i%$ i,$C$8 !*!5 9 ,!"$n 1) *+ (-58$5i -"$*$ 1)?14 8$5i< $n$k?$n$k 9 ,!"$n?0 %$8!n 2) *+ (-58$5i -"$*$ 1)?14 8$5i< $n -C$$ 4) *+ B$=$i% $n =$@< 2)11. 2 ATOFISIOLO'I ENYAKIT
M-k$ni*- %-5=$in@$ i$5- @$n+ $k!% *$!(!n @$n+ k5nik $($% i,$+i *-n=$i k-"*(k *%ik< -k5-%5ik< -k!$%i# $n +$n++!$n *%i"i%$. Di$5*%i; %-5=$i ,i"$ $$ ,$8$n @$n+ %i$k $($% i-5$( *-nin+k$%k$n*"$5i%$ $"$*"!*-n @$n+ *-n$5ik $i5 $5i ("$*$-8in++$ %-5=$i i$5-. Di$5- -k5-%5ik ,i"$ %-5=$i +$n++!$n %5$n(5% -"-k%5"i% ,$ik $,5,i @$n+ ,-5k!5$n+ $%$!(!n -k5-i @$n+ *-nin+k$%. Di$5- -k!$%i#< in#"$*$i $k$n *-n+$ki,$%k$n k-5!$k$n *!k$ ,$ik !! 8$"! *$!(!n !! ,-$5. Di$5- $($% %-5=$i $ki,$%"-,i8 $5i$%! *-k$ni*-. $$ in#-ki ,$k%-5i ($"in+ %i$k $$ !$ *-k$ni*- @$n+ ,-k-5=$ (-nin+k$%$n -k5-i !! $n (-n!5!n$n $,5,i i !!. In#-ki ,$k%-5i *-n@-,$,k$n in#"$*$i $n *-n+-"!$5k$n %kin @$n+ *-n@-,$,k$n %-5=$in@$ i$5-. In#-ki ,$k%-5i @$n+ in$i# *-n+$ki,$%k$n (-5$5$8$n $%$! $$n@$ "-!ki% $"$*#-- Z-in kk.< 2))4. 3
ALASAN EMILIHAN BENTUK SEDIAAN T$,"-% $"!% $$"$8 %$,"-% @$n+ i"$(ii ("i*-5/ 5-in $%$! (-n@$"!% "$inn@$ @$n+ ;;k @$n+ i%!=!k$n !n%!k -=!*"$8 $"$$n %-5*$!k !n%!k *-"in!n+i ,$8$n ,$% %-58$$( ($($5$n !$5$ $n k-"-*,$($n =!+$ i %!=!k$n !n%!k (-"-($$n ,$% %-5kn%5" $n (-"-($$n ,$% i !!. T$,"-% $"!% -n%-5ik *-5!($k$n %$,"-% @$n+ i $"!% -n+$n ("i*-5 @$n+ %i$k "$5!% $"$* $$* %-%$(i *!$8 %-5i"!i $"$* knii ,$$8 ($$ !!.
4
ALASAN EMILIHAN ZAT AKTIF Zin; *-5!($k$n *ik5n!%5i-n (-n%in+ ,$+i k--8$%$n. T-5$(i ink !n%!k i$5-
%-"$8 i5-k*-n$i $5i WHO $n UNI&EF -=$k %$8!n 2))4. K-%ik$ i,-5ik$n -"$* 1)?14 8$5i -"$*$ $n -%-"$8 i$5-< ink *$*(! *-n+!5$n+i !5$i $n %in+k$% k-($5$8$n i$5- W$"k-5 $n R,-5%< 2)1). Zink $($% *-*(-5;-($% 5-(i%-"i$i =$5in+$n @$n+ *-n+$"$*i k-5!$k$n< *-nin+k$%k$n i*!ni%$< $n *-*(-5;-($% (-n@-*,!8$n i$5- -8in++$ (-*,-5i$n (5-($5$% ink $k$n *-*(-5;-($% "$*$ 5$C$% in$( i 5!*$8 $ki%. S!$%! *-%$$n$"ii *-n+!n+k$(k$n !("-*-n%$i ink -;$5$ ,-5*$kn$ *-n!5!nk$n #5-k!-ni ,-5$% -5%$ *5,ii%$ i$5- $k!% H!5@$*in kk.< 2)13.
B-5$$5k$n !$%! (-n-"i%i$n< Zink $($% *-nin+k$%k$n (-5,$ik$n i$5- $k!%< *-n+!5$n+i *!$"< $n *-*i"iki k-;-n-5!n+$n $"$* *-nin+k$%k$n ,-,-5$($ +-"$=$"$ i$5-< -(-5%i $ki% (-5!%< #5-k!-ni ,!$n+ $i5 ,-$5< kni%-ni %in=$< *!n%$8< (-5!% k-*,!n+< $n +$nn+!$n $k%i#i%$ -8$5i?8$5i. K$5-n$ i%!< !("-*-n%$i ink $($% i$n++$( -,$+$i %-5$(i %$*,$8$n ($$ (-n-5i%$ i$5- -C$$ $k!% K%-5*$n kk.< 2)14. Indik!i :
-n+,$%$n i$5- ($$ $n$k F"#k$kin%&ik :
S-n+ $n +$5$*n@$ @$n+ k!5$n+ i-5$( $5i $"!5$n (-n;-5n$$n 2)?3)< !-n!*< $n i"-!*. S-n+ -n+-n i-5$( i i"-!* $n k"n *-n;i(%$k$n i5k!"$i -n%-5(8-%ik. S-%-"$8 (-n@-5$($n -n+ %-5ik$% ($$ (5%-in *-%$""%8in-in i$"$* !!. Zink ii%5i,!ik$n -;$5$ "!$ k- -"!5!8 %!,!8. T-5!%$*$ ii*($n $"$* -" $5$8 *-5$8< "-!ki%< %%< %!"$n+< k!"i%< +in=$"< ($nk5-$< 5-%in$< $n (5%$%. Zink i-k-k5-ik$n %-5!%$*$ i #-- ) $n 8$n@$ =-=$k @$n+ i%-*!k$n $"$* !5in< +in=$" *-*$ink$n (-5$n k-;i" $"$* *-n+$%!5 Zn $"$* %!,!8 B$=$i $n i=$@< 2)11. E'%k !#(in) :
M!$" $n *!n%$8 $n 5$$ %i$k n@$*$n ($$ (-5!% ISO< 2)14. S$*($i $$% ini ,-"!* $$ "$(5$n -#-k $*(in+ @$n+ ($5$8 $5i -+$"$ ,-n%!k !("-*-n ink @$n+ i+!n$k$n $"$* (-n+,$%$n i$5-.
0
ALASAN EMILIHAN ZAT TAMBAHAN $. ( *-5!($k$n $"$8 $%! @$n+ !*!* i+!n$k$n -,$+$i ,$8$n (-n+ik$% "$in @$i%! $($% ,-5#!n+i (-n+ik$% @$n+ ,$ik. ( "$5!% -*(!5n$ $"$* $i5 $n $($% ,-5(-5$n -,$+$i (-n+ik$% @$n+ ,$ik -n+$n ,$8$n (-n+ii +!"$ $n *-n+8$i"k$n i#$% $"i5 @$n+ ,$ik Ri$C$%i< 2)13. S$"$8 $%! ,$8$n (-n+ik
%$ @$n+ -5in+ i+!n$k$n $$"$8 < -,$+$i ,$8$n (-n+ik$% $($% i+!n$k$n $"$* ,-n%!k "$5!%$n ,-5$i5 *$!(!n $"k8" M$8$nini< 2)). ( ,-5C$5n$ (!%i8< %i$k ,-5$$< -5,!k @$n+ 8i+5k(ik< $($% ,-5#!n+i -,$+$i -in%-+5$n *-*,$n%! i"!i $n -,$+$i (-n+ik$%< (( -,$+$i ,$8$n (-n+ik$% -n+$n k-!n%!n+$n -,$+$i (-5-k$% @$n+ ,$ik $"$* (-"$5!% $i5 $n $"k8" B$nk-5 $n An-5n< 1G ,. L$k%$ ,in-5/#"$5in+ L$k%$ $($% ,-5#!n+i -,$+$i (-n+ii $"$* (-*,!$%$n %$,"-% $n k$(!". L$k%$ *-*(!n@$i %$,i"i%$ @$n+ ,$ik ,i"$ ik*,in$ik$n -n+$n $% $k%i#< ,$ik i+!n$k$n $"$* ,-n%!k 8i5$% $%$! $n8i5$%. H$5+$ "$k%$ 5-"$%i# "-,i8 *!5$8 AnC$5< 2)12. L$k%$ *-5!($k$n ,$8$n (-n+ii @$n+ ($"in+ ,$n@$k i+!n$k$n< 8$5+$n@$ *!5$8 $n *-5!($k$n ,$8$n (-n+ii @$n+ in-5%< -"$in i%! C$k%! 8$n;!5n@$ $n+$% ;-($% k$5-n$ i#$%n@$ "$5!% $i5 +$%inin+i8< 2))G. ;. -n@$"!% K""i;$% 3) D 09 *+ T$"k 19 *+ Ti%$n iki$ 4<4 *+ "i-%i"-n +"ikn 2<2 *+ Ai5 32) *L $. K""i;$% 3) D/ -!5$+i% -;$5$ !*!* i+!n$k$n $"$* #5*!"$i %$,"-% -,$+$i ,$8$n $"!% #i"*. K$5$k%-5i%ik k-"$5!%$n $n $"!% #i"* @$n+ %-5,-n%!k %-5+$n%!n+ $5i =-ni ("i*-5 @$n+ i+!n$k$n. (-n++!n$$n E!5$+i% k-5in+ !n%!k *-n+n%5" (-"-($$n $% $k%i# ($$ %$,"-% *$%5ik $$"$8 -ki%$5 0?2). S-$n+k$n ($$ *-%- k-*($ "$n+!n+ -ki%$5 1)? 0). ,. T$"k $($% i+!n$k$n -,$+$i $n%i;$k;. Ti%$n iki$ D$"$* ,i$n+ #$5*$i< %i%$ni!* iki$ i+!n$k$n -,$+$i $% (-*!%i8 $"$* !(-ni $"!% #i"*< %$,"-% $"!% +!"$ $n k$(!" +-"$%in. Ti%$ni!* iki$ $n+$% %$,i" ($$ %-*(-5$%!5 %in++i< ,-5C$5n$ (!%i8<$*5#< %i$k ,-5$$ $n %i$k 8i+5k(i. . "i-%i"-n +"ik" i+!n$k$n -,$+$i $+-n ("$%i-5
B-5$$5k$n !$%! (-n-"i%i$n %-58$$( (-n@$"!% ,$8$n k--*($% i$%$ *-5!($k$n (-n@$"!% @$n+ ,$ik !n%!k (-*,!$%$n %$,"-% $"!% -n%-5ik. 9
URAIAN BAHAN $. Zink Di%=-n *< 1: :2: N$*$ 5-*i ZINK Sinni* S-n+ A5 00< 3:/Zn -*-5i$n L+$* (!%i8 k-,i5!$n< "+$* ini ;!k!( *!$8 i%-*($ $n "i$% ($$ 11)?10) &< *-"-,!5 ($$ 41) & K-"$5!%$n L$5!% $"$* $$* k"5i$ -n;-5 $n $$* !"#$% -n;-5 -5%$ $$* ni%5$% -n;-5 -5%$ $"k$"i. -n@i*($n$n D$"$* C$$8 %-5%!%!( 5$($% K8$i$% S-,$+$i $%5i+-n ,. Di%=-n OM< 1: 01) N$*$ 5-*i OLIDOMUM N$*$ "$in i"iini" (i5"i!* -*-5i$n S-5,!k (!%i8 / (!%i8 k-k!nin+$n ,-5,$! "-*$8 / %i$k ,-5,$! K-"$5!%$n
<8i+5k(ik M!$8 "$5!% $"$* $i5< $"$* -%$n" 0 $n $"$* k"5#5* k-"$5!%$n %-5+$n%!n+ $5i ,,% *"-k!" 5$%$?5$%$<
(5$k%i %i$k "$5!% $"$* -%-5 . -n@i*($n$n D$"$* C$$8 %-5%!%!( 5$($% K-+!n$$n Z$% (-n+ik$% $n $% (-n+8$n;!5 ;. L$k%$ N$*$ 5-*i Sinni* BM Ti%ik "-"-8
LA&TOSUM "$k%$/$;;8$5!* "$;%i 39<3) 223) !n%!k "$k%$ $8i5!< 202<2) !n%!k J "$k%$
$n8i5!< $n 232) !n%!k "$k%$ $n8i5! k*-5i$". R!*! *"-k!" &12H22O11.H2O R!*! %5!k%!5 -*-5i$n -5,!k 8$,"!5< (!%i8< %i$k ,-5,$!< 5$$ $+$k *$ni
K-"$5!%$n
"$5!% $"$* 9 ,$+i$n $i5< "$5!% $"$* 1 ,$+i$n $i5 *-nii8<
!k$5 "$5!% $"$* -%$n" 0) (< (5$k%i %i$k "$5!% $"$* k"5#5* ( $n $"$* -%-5 (. -n@i*($n$n D$"$* C$$8 %-5%!%!( ,$ik K8$i$% S-,$+$i ,in-5
:
ERHITUN'AN BAHAN
G
METODE EMBUATAN
DAFTAR USTAKA An-"< H. &.< 2)11< -n+$n%$5 ,-n%!k -i$$n #$5*$i -ii 4< UI 5-< 7$k$5%$. AnC$5< E.< 2)12< Eki(i-n $"$* -i$$n #$5*$i k$5$k%-5i$i $n $("ik$i< Di$n R$k@$%< 7$k$5%$. B$=$i%< &. D$n i=$@ T.< 2)11< R"- # Zin; in -i$%5i; Di$558-$< Ini$n 7 8$5*$;"< " 433. Di%=-n OM< 1:< Farmakope Indonesia Edisi III < D-($5%-*-n K--8$%$n R-(!,"ik Inn-i$< 7$k$5%$ Di%=-n OM< 10< Farmakope Indonesia Edisi IV < D-($5%-*-n K--8$%$n R-(!,"ik Inn-i$< 7$k$5%$ H!5@$*in< R.< R!*$C$%i< An$n+ '.< 2)13< 8!,!n+$n (-*,-5i$n Zink Zn ($$ $n$k i$5- -n+$n "$*$ 5$C$% in$( i 5!*$8 $ki% KU M!8$*$i@$8 S!5$k$5%$< N$k$8 !,"ik$i. K%-5*$n< D.< M$5;-""! S.< I5$n H.< $n L$5$ B.< 2)14< %8- -##-;% # Zin; S!("-*-n%$%in in A!"% $%i-n% Ci%8 A;!%-; D$558-$< %8- inn-i$n =5n$" # +$%5-n%-5"+i-< 8-($%"+@ $n i+-%i- -n;(@< " 102.
RC-< R. &.< $!" 7. S.< $n M$5i-n E. .< 2))< Handbook of Pharmaceutical Excipients 6th edition &8i;$+< 8$5*$;-!%i;$" 5-. W$"k-5< &. L. D$n R,-5% E. B.< 2)1)< Zink #5 T8- %5-$%*-n% # i$558-$ -##-;% n i$558-$ *5,ii%@< *5%$"i%@< $n i;i-n;- # #!%!5- -(i-< In%-5n$%in$" =!5n$" # -(i-*i"+i< ". 3. Wi< H.< 2)13< I"*! M-5$;ik O,$% !n%!k A(%-k-5< D?M-ik$< Y+@$k$5%$. Z-in< U.< K8$"i H. S.< $n 7i$ '.< 2))4< Di$5- Ak!% Di-,$,k$n B$k%-5i< R-(i%5@.