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Resumen antimicrobianos - Medicina Veterinaria
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Resumen antimicrobianos - Medicina Veterinaria
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J.I.Armendano
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Generalidades de Antimicrobianos
Guia
LERCENGAG@ÃE D^XDNKEA „ 288; LÅRCENG^ EOVKCKNRGBKEOG^ EOVKCKNRGBKEOG^
RD^TCDO NAE^KLKNENKÞO FD AG^ EOVKCKNRGBKEOG^ ^D@ÝO ^T GRK@DO OEVTREAD^ *EOVKBKÞVKNG^+ Xdoknkakoe~ Xdoknkakoe @
Vdvrenknakoe~ Gzkvdvrenknakoe! nagrvdvrenknakoe! nagrvdvrenknakoe! vdvrenknakoe
Ndleag~xgrkoe~ Ndleag~xgrkoe X Ndleag~xgrkoe O Ndleag~xgrkoe N
Ndlecknkoe~ Ndlecknkoe N
BKG^KOVËVKNG^ Xdoknkakoe~ Xdoknkakoe @ Xdoknkakoe \
^DCK^KOVËVKNG^ Xdoknkakoe~ Xdodvecevg *xrg#xdoknkakoe @+ Cdvknkakoe! oelnkakoe K~gze~gakaxdoknkakoe~= gzenkakoe! nagzenkakoe! fknagzenkakoe! lagzenkakoe Eckogxdoknkakoe~= Eckogxdoknkakoe~= xrg#ecxknkakoe~! xrg#ecxknkakoe~! ecxknkakoe! ecxknkakoe! ecgzknkakoe ecgzknkakoe Trdkfgxdoknkakoe~= xkxdrenkakoe! xkxdrenkakoe! e}agnkakoe! cd}agnkakoe Nerbgzkxdoknkakoe~= nerbdoknkakoe! nerbdoknkakoe! vknernkakoe! vdcgnkakoe Eckfkogxdoknkakoe~= Eckfkogxdoknkakoe~= cdnkakoec Vdvrenknakoe~ Vdvrenknakoe
Vdvrenknakoe~ Fgzknknakoe! ckognknakoe
Eovkckngbenvdrkeog~ Eovkckngbenvdrkeog~ fd xrkcdre aãode Rklecxkoe
Eovkckngbenvdrkeog~ Eovkckngbenvdrkeog~ fd xrkcdre aãode K~goke}kfe! dvecbtvga! xkre}koeckfe
Ndleag~xgrkoe~
Okvrgltreog~ Ltre}gakfgoe! okvrgltre}goe! okvrgltreovgãoe! okltrevda! okltrgutkoe
Xrkcdre `dodrenkþo= n dlexkrkoe! dlexkrkoe! ndleagvkoe! ndlefrgzka!
ndlrefkoe! ndlrefkoe! ndleag`aknkoe! ndleag`aknkoe! ndlendvrka! ndleagrkfkoe! ndle}gakoe! ndleadzkoe! ^d`tofe `dodrenkþo= ndltrgzkcd! ndlenagr! ndleceofga! Vdrndre `dodrenkþo= ndldvecdv! ndlkzkce! ndlcdogzkce! ndlutkogoe! ndlvk}gzkce! ndl~tagfkoe! ndlve}kfkce! ndl# vrkezgod! ndlvkgltr! cgzeaenvec Nterve `dodrenkþo= ndldxkoe! ndlxkrgoe! Ndlecknkoe~ Konatkfe~ do ae ~d`tofe `dodrenkþo fd ndleag~xgrkoe~=
Ndlgzkvkoe! ndlcdve}ga! ndlgvdveo Konatkfe~ do ae vdrndre `dodrenkþo fd ndleag~xgrkoe~=
Ndlgvezkoe! ndlgxdre}goe Cgogbenvec~ E}vrdgoec E}vrdgoec
Nerbexdodc~ Kckxdodc
Eckog`atnþ~kfg~ D~vrdxvgcknkoe! ieoecknkoe! vrgbecknkoe! `dovecknkoe! exrecknkoe! odgcknkoe
Eckog`atnþ~kfg~ Fkjkfrgd~vrdxvgcknkoe! eckienkoe! odvkacknkoe
Cenrþakfg~ Drkvrgcknkoe! vrgadoefgcknk# oe! vkag~koe! d~xkrecknkoe
Cenrþakfg~ E}kvrgcknkoe! E}kvrgcknkoe! vdakvrgcknkoe! vdakvrgcknkoe! vtaevrgcknkoe! vtaevrgcknkoe! vkectakoe! vkectakoe! vkack# vkack# ng~koe
Akong~eckfe~ Akongcknkoe
Akong~eckofe~ Nakofecknkoe! xkrakcknkoe
Eckognknakvgad~ D~xdnvkogcknkoe Kgoþ~lgrg~ Cgodo~koe! Ae~eagnkf
^KOVËVKNG^ *UTKCKGVDRÅXKNG^+
Okvrgkckfe}gad~ Cdvrgokfe}ga! Cdvrgokfe}ga! fkcdvrkfe}ga! vkokfe}ga! kxrgok# fe}ga! rgokfe}ga Utkogagoe~ Xrkcdre `dodrenkþo= ånkfg oeakfãzkng! ånkfg
gzgaãokng! ånkfg xkxdcãfkng! ånkfg xkrgckfãok# ng! nkogzenkoe! latcdutkoe ^d`tofe `dodrenkþo *nae~d K+= xdlagzenkoe! xdlagzenkoe! ogrlagzenkoe! dogzenkoe! agcdlagzenkoe ^d`tofe `dodrenkþo `dodrenkþo *nae~d KK+= dorglagzenkoe! nkxrglagzenkoe! cerbglagzenkoe! glagzenkoe Vdrndre `dodrenkþo= ad|glagzenkoe! grbklagze# nkoe! `rdxelagzenkoe! ~xerlagzenkoe! feog# lagzenkoe! lagzenkoe! `evklagzenkoe `evklagzenkoe Nterve `dodrenkþo= cgzklagzenkoe! vrg|elagze# nkoe! nakoelagzenkoe! `dcklagzenkoe Eoldokngad~ Nagreoldoknga! Nagreoldoknga! vkeoldoknga! vkeoldoknga! lagrldoknga
Gvrg~ Rklecxkoe
^taleckfe~ ^tale~ fd ennkþo ~k~vëckne ngrve=
Xrgovg~ka rtbrtc! ~taleokaeckfe! ~talecdve}k# oe *g ~talefkckfkoe+! ~talk~gze}ga! ~talk~gckfk# oe! ~talecdvke}ga! ~talexkrkfkoe ~talexkrkfkoe ^tale~ fd ennkþo ~k~vëckne cdfke=
~talecdvgze}ga! ~talefke}koe! ~talevke}ga! ~talecdre}koe ^tale~ fd ennkþo ~k~vëckne aer`e=
~talefkcdvgzkoe! ~talecdvgzkxkrkfe}koe! ~tale# nagrgxkrkfe}koe! ~talecdvgzkfke}koe ^tale~ fd ennkþo ~k~vëckne tavreaer`e=
~talecdvgxkre}koe! ~talefgzkoe Gvrg~ Ånkfg lt~ãfkng! lt~ãfkng! |kr`kokecknk# |kr`kokecknk# oe! og|gbkgnkoe! lg~lgcknkoe
^tale~ fd ennkþo dovërkne=
lveaka~tlevke}ga lveaka~tlevke}ga *g ~taleveakfkoe+! ~taleveakfkoe+! ~tnnkoka~tale ~tnnkoka~tale## vke}ga *g ~tale~tnnkfkoe+! ~tale`teokfkoe! ~tale~eae}koe *g ~eae}gxkrkoe+! ~taleutkogzeakoe ^taleckfe~ fd t~g vþxkng=
~talendveckfe! ~talefke}koe er`ëovkne! ~tale# ckaþo *g endvevg fd celdokfg+ Fkeckogxkrkckfkoe~ Xkrkcdveckoe! vrkcdvgxrkc! grcdvgxrkc! beutkagxrkc! efkvgxrkc Gvrg~ Lg~lgcknkoe *envteacdovd+! nerbefgz
MGEUTÃO K@OENKG ERCDOFEOG
5
RD^TCDO#LÅRCENG^
EOVKCKNRGBKEOG^
NAE^KLKNENKÞO FD AG^ EOVKCKNRGBKEOG^ ^D@ÝO ^T OEVTREAD]E UTÃCKNE ÅNKFG
EOLÞVDRKNG
ODTVRG
BÅ^KNG
Bdve#aenvåckng~ Rklecxkoe Og|gbkgnkoe Lg~lgcknkoe Ånkfg lt~ãfkng ^taleckfe~ Okvrgltreog~
Vdvrenknakoe~ Utkogagoe~
Eoldokngad~
Cenrþakfg~ Akong~eckfe~ Eckog`atnþ~kfg~ Eckognknakvgad~ Fkeckogxkrkckfkoe~ Xgakckzkoe~ Okvrgkckfe}gad~
NAE^KLKNENKÞO FD AG^ EOVKCKNRGBKEOG^ ^D@ÝO ^T AKXG^GATBKAKFEF EAVE AKXG^GATBKAKFEF
CGFDREFE AKXG^GATBKAKFEF
BEME AKXG^GATBKAKFEF
Ecxknkakoe Rklecxkoe Cenrþakfg~ Akong~eckfe~ Eoldokngad~ Fkeckogxkrkckfkoe~ K~goke}kfe Dvecbtvga Xkre}koeckfe Okvrgkckfe}gad~ Ånkfg lt~ãfkng
Xdoknkakoe~ *dzndxvg ecxknkakoe+ Ndleag~xgrkoe~ Ndlecknkoe~ Utkogagoe~ ^taleckfe~ Vdvrenknakoe~
Xgakckzkoe~ Eckog`atnþ~kfg~ Eckognknakvgad~ \eongcknkoe7
NAE^KLKNENKÞO FD AG^ EOVKCKNRGBKEOG^ ^D@ÝO ^T ENNKÞO EOVKCKNRGBKEOE BENVDRKNKFE^
BENVDRKG^VÅVKNG^
LÅRCENG^ UTD KOJKBDO AE ^ÃOVD^K^ FD XERDF NDATAER Bdve#aenvåckng~= xdoknkakoe~! ndleag~xgrkoe~! ndlecknkoe~! cgogbenvec~! nerbexdodc~ @akngxdxvãfkng~= |eongcknkoe Xgakxdxvãfkng~= benkvrenkoe Eovk#ckngbenvdrke~= k~goke}kfe! dvecbtvga! xkre}koeckfe Gvrg~= lg~lgcknkoe LÅRCENG^ UTD KOJKBDO AE LTONKÞO FD AG^ ÅNKFG^ OTNADKNG^ Utkogagoe~ Okvrgltreog~ Okvrgkckfe}gad~ Rklecxkoe Og|gbkgnkoe Gvrg~= nerbefgz FRG@E^ UTD EAVDREO AE XDRCDEBKAKFEF FD AE CDCBREOE NDATAER
FRG@E^ UTD EAVDREO AE XDRCDEBKAKFEF FD AE CDCBREOE NDATAER
Xgakckzkoe~
Kgoþ~lgrg~= cgodo~koe! ae~eagnkf
LÅRCENG^ UTD EAVDREO AE ^ÃOVD^K^ FD XRGVDÃOE^ Eckog`atnþ~kfg~
LÅRCENG^ UTD EAVDREO AE ^ÃOVD^K^ FD XRGVDÃOE^ Eckognknakvgad~ Vdvrenknakoe~ Cenrþakfg~ Akong~eckfe~ Eoldokngad~ Gvrg~= ånkfg lt~ãfkng! |kr`kokecknkoe
Eoldokngad~= da lagrldoknga xg~dd toe ennkþo benvdrknkfe ngondovrenkþo fdxdofkdovd lrdovd e Ceoojdkcke jdcga{vkne *dz Xe~vdtrdaae jdcga{vk# ne+! Xe~vdtrdaae ctavgnkfe d Jk~vgxjkat~ ~gcok *d~ Jedcgxjkat~ ~gcot~+/
LÅRCENG^ EOVKCDVEBGAKVG^ ^taleckfe~ ) fkeckogxkrkckfkoe~
2
LÅRCENG^ EOVKCDVEBGAKVG^ ^taleckfe~ Fkeckogxkrkckfkoe~
LERCENGAG@ÃE D^XDNKEA „ 288;
NAE^KLKNENKÞO FD AG^ EOVKCKNRGBKEOG^ ^D@ÝO ^T NKOËVKNE FD ENNKÞO VKDCXG FDXDOFKDOVD
NGONDOVRENKÞO FDXDOFKDOVD
Bdve#aenvåckng~ Vdvrenknakoe~ Akng~eckfe~ ^taleckfe~ Fkeckogxkrkckfkoe~ Eckognknakvgad~
Eckog`atnþ~kfg~ Utkogagoe~ Okvrgkckfe}gad~ Okvrgltreog~7 Xgakckzkoe~
Cenrþakfg~= drkvrgcknkoe! vrgadofgcknkoe! vkag~koe! d~xkrecknkoe! vkect# akoe! vkackng~koe
Cenrþakfg~= e}kvrgcknkoe! vtaevrgcknkoe! vdakvrgcknkoe
Eoldokngad~= nagreoldoknga! vkeoldoknga! lagrldoknga
Eoldokngad~= da lagrldoknga envýe do lgrce ngondovrenkþo fdxdofkdovd lrdovd e Ceoojdkcke jdcga{vkne *dz Xe~vdtrdaae jdcga{vkne+! Xe~vdtrdaae ctavgnkfe d Jk~vgxjkat~ ~gcok *dz Jedcgxjkat~ ~gcot~+
Gvrg~= |kr`kokecknkoe! ånkfg lt~ãfkng! lg~lgcknkoe! k~goke}kfe! dvecbtvga! xkre}koeckfe
MGEUTÃO K@OENKG ERCDOFEOG
>
RD^TCDO#LÅRCENG^
EOVKCKNRGBKEOG^
CDNEOK^CG FD ENNKÞO FD AG^ FKLDRDOVD^ EOVKCKNRGBKEOG^ Bdve#aenvåckng~ \eongcknkoe
Kojkbknkþo fd ae ~ãovd~k~ fd xerdf ndataer
Kojkbknkþo fd do}kce~ vreo~xdxvkfe~e~ *xrkonkxeacdovd+ Kojkbknkþo fd do}kce~ nerbgzkxdxvkfe~e~ Kojkbknkþo fd ae do}kce vreo~`atng~kfe~e
Benkvrenkoe
Kojkbknkþo fd ae k~gxrdokalg~leve~e
Lg~lgcknkoe
Kojkbknkþo fd ae d}kce dogaxkrt|evg#vreo~ldre~e Kojkbknkþo fd ae vreo~nrkxnkþo fda `do utd ngfklkne toe do}kce dogkardftnve~e fda ngcxadmg fd ae ånkfg `re~g ~kovdve~e KK *fd~evtre~e fd ånkfg~ `re~g~+
K~goke}kfe Dvecbtvga Xkre}koeckfe
Kojkbknkþo fda ngcxadmg do}kcåvkng fd ae ånkfg `re~g ~kovdve~e K
Kojkbknkþo fd ae ~ãovd~k~ fd ånkfg~ cknþakng~
Utkogagoe~ Kojkbknkþo fd ae vgxgk~gcdre~e K\ do @rec xg~kvk|g~
Okvrgltreog~ Okvrgkckfe}gad~
Og|gbkgnkoe
Nerbefgz Eckog`atnþ~kfg~ Vdvrenknakoe~ \kr`kokecknkoe C Eckognknakvgad~ Eavdrenkþo fd ae ~ãovd~k~ fd xrgvdãoe~
Ånkfg lt~ãfkng Cenrþakfg~ Akng~eckfe~ Eoldokngad~
Eavdrenkþo fd ae xdrcdebk# akfef fd ae cdcbreoe ndataer
Eovkcdvebgakvg~
Xgakckzkoe~ Cgodo}koe Ae~eagnkf ^taleckfe~
Fkeckogxkrkckfkoe~
6
Kojkbknkþo fd ae ~ãovd~k~ fd do}kce~ utd kovdr|kdodo do ae ~ãovd~k~ fd ånkfg~ cknþakng~ Kojkbknkþo fd ae vreo~ldrdonke fd ånkfg~ cknþakng~ jenke ae xerdf benvdrkeoe
~gcdre~e KK+ do @rec od`evk|e~
Kojkbknkþo fd ae ltonkþo fda ånkfg otnadkng
^d kojkbd ae vreo~`atng~kfenkþo ^d kojkbd ae rd`dodrenkþo fda aãxkfg vreo~xgr# vefgr fd cdcbreoe ^d kojkbd ae ~ãovd~k~ fd xrdntr~grd~
Kojkbknkþo fd ae do}kce erebkog~ka#vreo~ldre~e
Kojkbknkþo fd ae ~tbtokfef ε fd ae FOE#`kre~e *g vgxgk#
Rklecxkoe
^d kojkbd ae~ vreo~xdxvkfenkþo
Kojkbknkþo fd ae do}kce ERO xgakcdre~e EFO fdxdofkdovd *cdfkeovd tokþo e ae ~tbtokfef β+
Fd`refenkþo fda EFO xgr x rgftnvg~ fd rdftnnkþo utd ~d lgrceo do ae benvdrke Fd`refenkþo fda EFO xgr x rgftnvg~ fd rdftnnkþo utd ~d lgrceo do ae benvdrke Kojkbknkþo fd ae do}kce FOEe~e 5 Kojkbknkþo fd ae ~tbtokfef β fd ae do}kce FOE#`kre~e
Fd`refenkþo fda EFO xgr x rgftnvg~ fd rdftnnkþo utd ~d lgrceo do ae benvdrke Tokþo e ~tbtokfef rkbg~gcea >8 ^ Adnvtre drrþode fda EROc Tokþo e ~tbtokfef rkbg~gcea >8 ^ Kojkbknkþo fd ae tokþo fda eckogenka#EROv ea ~kvkg E fd ae ~tbtokfef rkbg~gcea Tokþo e ~tbtokfef >8 ^ Kojkbknkþo fd ae vreo~agnenkþo Tokþo e ~tbtokfef 48 ^ Kojkbknkþo fd ae vreo~agnenkþo Tokþo e ae ~tbtokfef rkbg~gcea 48 ^ Kojkbknkþo fd ae vreo~agnenkþo cdfkeovd kojkbknkþo fd ae do}kce vreo~agne~e Tokþo e ae ~tbtokfef rkbg~gcea 48 ^ Kojkbknkþo fd ae vreo~xdxvkfenkþo kojkbknkþo fd ae do}kce xdxvkfka#vreo~ldre~e Fd~gr`eok}enkþo fd ae d~vrtnvtre fda AX^ *cdfkeovd kovdr# ennkþo ngo ae rd`kþo eokþokne fda aãxkfg E+ Fd~gr`eok}enkþo fd ae cdcbreoe kovdroe
Kojkbknkþo fd ae ~ãovd~k~ fd EFO *^d kojkbd ae rdcgnkþo fda ~txdrdorrgaae# ckdovg xg~kvk|g utd ~d `dodre xgr fdaeovd fda xtovg fd rdxaknenkþo fda EFO+ Kojkbknkþo fd ae ~ãovd~k~ fd EFO *^d kojkbd ae ~dxerenkþo fda FOE ~kovdvk}efg fd eutda utd ltd tvkak}efg ngcg xaeovkaae+ Kojkbknkþo fd ae ~ãovd~k~ fd ERO *Kojkbknkþo fd ae vreo~nrkxnkþo fda EFO+ Fd`refenkþo fda EFO Fd`refenkþo fda EFO ^d kcxkfd ae rdxerenkþo fda EFO xgr ae do}kce FOE~e Kojkbknkþo fd ae ~ãovd~k~ fd EFO *^d kojkbd ae rdcgnkþo fda ~txdrdorrgaae# ckdovg xg~kvk|g utd ~d `dodre xgr fdaeovd fda xtovg fd rdxaknenkþo fda EFO+ Fd`refenkþo fda EFO Kojkbknkþo fd ae ~ãovd~k~ fd EFO ^ãovd~k~ fd x rgvdãoe~ drrþode~ Kojkbknkþo fd ae dago`enkþo fd ae nefdoe xgak# xdxvãfkne *kcxkfdo ae tokþo fd eckogånkfg~+
Kojkbknkþo fd ae dago`enkþo fd ae nefdoe xgak# xdxvãfkne *kcxkfdo ae vreo~agnenkþo+
Kojkbknkþo fd ae dago`enkþo fd ae nefdoe xgak# xdxvãfkne *kcxkfdo ae vreo~xdxvkfenkþo+ Dldnvg vdo~kgenvk|g ~gbrd ae cdcbreoe kovdroe { ae cdcbreoe dzvdroe *AX^+
Dldnvg kgoþlgrg
^d eavdre da dutkakbrkg jkfrgdadnvrgaãvkng { dodr`ëvkng fd ae nëatae! ~d eavdre da xJ fd ae nëatae
Kojkbknkþo fd ae do}kce fkjkfrgxvdrgevg ~kovdve~e *FJX^+ Kojkbknkþo fd ae do}kce fkjkfrglgaevg ~kovdve~e *FJL^+ Kojkbknkþo fd ae do}kce fkjkfrglgaevg rdftnve~e *FJLR+
Kojkbknkþo fd ae ~ãovd~k~ fd fdrk|efg~ fda ånkfg lþakng! eavdråofg~d ae ~ãovd~k~ fd EFO! ERO { xrgvdãoe~
LERCENGAG@ÃE D^XDNKEA „ 288;
D^XDNVRG FD ENVK\KFEF @DODREA FD AG^ FKLDRDOVD^ EOVKCKNRGBKEOG^ Edrgbkg~ @rec ) @rec # Frg`e~ kojkbkfgre~ fd ae ~ãovd~k~ fd xerdf ndataer Xdoknkakoe @ ) Xdoknkakoe \ ) Cdvknkakoe ) Oelnkakoe K~gze~gakaxdoknkakoe~ ) Xdoknkakoe~ ~ Eckogxdoknkakoe~ ) g n k Nerbgzkxdoknkakoe~ ) c å v Trdãfgxdoknkakoe~ ) n e a # Eckfkogxdoknkakoe~ # e v d Xrkcdre `dodrenkþo ))) B ^d`tofe `dodrenkþo )) Ndleag~xgrkoe~ { ndlecknkoe~ Vdrndre `dodrenkþo ) Nterve `dodrenkþo )))) Cgogbenvec~ # Nerbexdodc~ ) \eongcknkoe ) Benkvrenkoe ) Lg~lgcknkoe ) K~goke}kfe Dvecbtvga Xkre}koeckfe Frg`e~ utd eavdreo ae xdrcdebkakfef fd ae cdcbreoe ndataer Xgakckzkoe~ # Kgoþlgrg~ ) Frg`e~ utd eavdreo ae ltonkþo fd ag~ ånkfg~ otnadkng~ Xrkcdre `dodrenkþo # ^d`tofe `dodrenkþo *nae~d K+ )'# ^d`tofe `dodrenkþo *nae~d KK+ Utkogagoe~ ))'# Vdrndre `dodrenkþo ))'# Nterve `dodrenkþo )))'# Rklecxkoe ) Okvrtltreog~ ) Okvrgkckfe}gad~ # Og|gbkgnkoe ) Nerbefgz Frg`e~ utd eavdreo ae ~ãovd~k~ fd xrgvdãoe~ D~vrdxvgcknkoe Fkjkfrgd~vrdxvgcknkoe )'# Eckog`atnþ~kfg~ Ieoecknkoe Gvrg~ eckog`atnþ~kfg~ )'# Eckognknakvgad~ # Ckognknakoe ) Vdvrenknakoe~ Gvre~ vdvrenknakoe~ ) \kr`kokecknkoe ) Akong~eckfe~ ) Eoldokngad~ ) Drkvrgcknkoe ) Vkag~koe ) D~xkrecknkoe ) Cenrþakfg~ E}kvrgcknkoe Vtaevrgcknkoe ) Vkectakoe Vkackng~koe Ånkfg lt~ãfkng ) Frg`e~ eovkcdvebgakvg~ ^taleckfe~ ) Fkeckogxkrkckfkoe~ ) ^taleckfe~ ) fkeckogxkrkckfkoe~ )
Eoedrgbkg~
Ckngxae~ce~
Naeckfke~
Rknidvv~ke~
Ckngbenvdrke~
Xrgvg}gg~
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MGEUTÃO K@OENKG ERCDOFEOG
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4
RD^TCDO#LÅRCENG^
EOVKCKNRGBKEOG^
Envk|kfef xrkonkxeacdovd lrdovd e @rec xg~kvk|g~
Envk|kfef xrkonkxeacdovd lrdovd e @rec od`evk|g~
Envk|kfef lrdovd e @rec xg~kvk|g~ { @rec od`evk|g~
Envk|kfef lrdovd e ^vexj{agngnnt~ etrdt~ rd~k~vdovd~ e ae cdvknkakoe *CR^E+
Envk|kfef lrdovd e X~dtfgcgoe~ edrt`kog~e
Envk|kfef lrdovd e eoedrgbkg~
Envk|kfef lrdovd e ckngxae~ce~ Envk|kfef lrdovd e naeckfke~ Envk|kfef lrdovd e rknidvv~ke~
Envk|kfef lrdovd e ckngbenvdrke~
Envk|kfef lrdovd e xrgvg}gerkg~
# Xdoknkakoe @! xdoknkakoe \! cdvknkakoe! oelnkakoe! k~gze~gakaxdoknkakoe~! ndleag~xgrkoe~ { ndlecknkoe~ fd xrkcd# re `dodrenkþo! |eongcknkoe! benkvrenkoe # Kgoþlgrg~ # Utkogagoe~ fd nterve `dodrenkþo! rklecxkoe # \kr`kokecknkoe! akong~eckfe~! drkvrgcknkoe! d~xkrecknkoe! vkag~koe! ånkfg lt~ãfkng # Eckfkogxdoknkakoe~! ndleag~xgrkoe~ { ndlecknkoe~ fd vdrndre `dodrenkþo! cgogbenvec~ # Xgakckzkoe~ # Utkogagoe~ fd xrkcdre `dodrenkþo! okvrgkckfe}gad~ # Eckog`atnþ~kfg~ # Eckogxdoknkakoe~! nerbgzkxdoknkakoe~! trdkfgxdoknkakoe~! ndleag~xgrkoe~ { ndlecknkoe~ fd ~d`tofe { nterve `dodrenkþo! nerbexdodc~! lg~lgcknkoe # Utkogagoe~ fd ~d`tofe { vdrndre `dodrenkþo9 okvrgltreog~! og|gbkgnkoe # Vdvrenknakoe~! e}kvrgcknkoe! vtaevrgcknkoe! vkectakoe! vkackng~koe! eoldokngad~ # Frg`e~ eovkcdvebgakvg~ # \eongcknkoe # Cgzklagzenkoe! rklecxkoe # Vrkcdvgxrkc#~talecdvgze}ga # Nerbgzkxdoknkakoe~! trdkfgxdoknkakoe~! ea`toe~ ndleag~xgrkoe~ { ndlecknkoe~ fd vdrndre `dodrenkþo! ndle# ag~xgrkoe~ fd nterve `dodrenkþo! cgogbenvec~ { nerbexdodc~ # Xgakckzkoe~ # Utkogagoe~ fd ~d`tofe { vdrndre `dodrenkþo # Eckog`atnþ~kfg~ *dzndxvg d~vrdxvgcknkoe! fkjkfrgd~vrdxvgcknkoe { ieoecknkoe+ # Bdve aenvåckng~ *dzndxvg eckfkogxdoknkakoe~ { cgogbenvec~+! |eongcknkoe! benkvrenkoe { lg~lgcknkoe # Kgoþlgrg~ # Frg`e~ utd eavdreo ae ltonkþo fd ag~ ånkfg~ otnadkng~ *dzndxvg ae~ utkogagoe~ fd xrkcdre! ~d`tofe { vdrndre `dodrenkþo+ # Frg`e~ utd eavdreo ae ~ãovd~k~ fd xrgvdãoe~ *dzndxvg ag~ eckog`atnþ~kfg~ { eckognknakvgad~+ # ^taleckfe~ ) fkeckogxkrkckfkoe~ # Utkogagoe~ fd ~d`tofe `dodrenkþo nae~d KK! vdrndre `dodrenkþo { nterve `dodrenkþo9 Okvrgltreog~ # Frg`e~ utd eavdreo ae ~ãovd~k~ fd xrgvdãoe~ # Utkogagoe~ fd ~d`tofe `dodrenkþo nae~d KK! vdrndre `dodrenkþo { nterve `dodrenkþo9 Rklecxkoe! Nerbefgz # Vdvrenknakoe~! Cenrþakfg~! ^taleckfe~ # ^taleckfe~ ) Fkeckogxkrkckfkoe~ # Utkogagoe~ fd ~d`tofe `dodrenkþo nae~d KK! vdrndre `dodrenkþo { nterve `dodrenkþo # Vdvrenknakoe~! Eoldokngad~! Cenrþakfg~ # K~goke}kfe! dvecbtvga! xkre}koeckfe # Utkogagoe~ fd ~d`tofe `dodrenkþo nae~d KK! vdrndre `dodrenkþo { nterve `dodrenkþo9 Rklecxkoe # D~vrdxvgcknkoe! Fkjkfrgd~vrdxvgcknkoe! Ieoecknkoe! Ckognknakoe! Ånkfg lt~ãfkng # ^taleckfe~ # Kgoþlgrg~ # Rklecxkoe! Okvrgltreog~! Okvrgkckfe}gad~! Nerbefgz # Vdvrenknakoe~! \kr`kokecknkoe! Akong~eckfe~! D~vrdxvgcknkoe! D~xkrecknkoe # Frg`e~ eovkcdvebgakvg~
EOVKCKNRGBKEOG^ NGO XDODVRENKÞO KOVRENDATAER *NËATAE^ FDA JG^XDFEFGR + − Cenrþakfg~= eaneo}eo dad|efe~ ngondovrenkgod~ kovrendataer { ~tbndataercdovd! { xg~ddo dad|efe envk|kfef eovkcknrg # bkeoe do d~vg~ ~kvkg~/ − Akong~eckfe~= eaneo}eo btdoe~ ngondovrenkgod~ kovrendataerd~! xdrg nerdndo fd kcxgrveovd~ dldnvg~ eovkcknrgbkeog~ do d~vg~ ~kvkg~/ − Eoldokngad~ − Eovk#ckngbenvdrke~ fd xrkcdre aãode *k~goke}kfe! dvecbtvga! xkre}koeckfe { rklecxkoe+
EOVKCKNRGBKEOG^ NGO DLDNVG XG^V#EOVKBKÞVKNG Da dldnvg xg~v#eovkbkþvkng *DXE+ d~ ae ~txrd~kþo fda nrdnkckdovg benvdrkeog xgr to vkdcxg fdvdrckoefg! dmdrnkfg xgr ae frg`e do ngondovrenkgod~ cdogrd~ e ae NKC! atd`g fd utd ae~ benvdrke~ je{eo ~kfg dzxtd~ve~ e ngondovrenkgod~ dldnvk|e~ fd ae frg`e *ce{grd~ e ae NKC+/ Xdoknkakoe~= DXE lrdovd ^vexj{agngnnt~ etrdt~ ~do~kbad~ Ndleag~xgrkoe~= DXE lrdovd e benvdrke~ @rec xg~kvk|e~ Eckog`atnþ~kfg~ Utkogagoe~
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