IMMUNOHEMATOLOGY IMMUNOHEMATOLOGY (BLOOD BANKING) BA NKING)
Midterm Examination I.
MULTIPLE CHOICE
1. The following following blood blood preserva preservatives tives have have a storage time time of 21 days at 1-6 OC, EXCET! a. "C# b. C2# $. C#"-1 d. C# 2. The preferr preferred ed storage storage time and temperat%re temperat%re for for platelet platelet $on$entrates $on$entrates prepared by $entrif%gation is! a. & da days at 1-6OC b. & day days s at at 2'2'-2( 2(OC $. & da days at 2(-2) -2) OC d. & day days s at at 2&2&-*' *'OC *. +lood +lood $an $an be store stored d in C#" C#"-1 -1 at 1-6 1-6 OC for how many days a. (2 b. *& $. 21 d. ) (. Citrate-pho Citrate-phosphat sphate-de e-detro trose se C#/, an improved improved preservati preservative ve whi$h event%ally repla$ed "C# as the standard preservative sol%tion was introd%$ed by 0000000 in 1&)! a. and andst ste einer iner b. 3i$4s $. #rew d. 5ibson &. ho dis$over dis$overed ed the "+O "+O blood blood gro%p gro%p system 7ame 7ame $hoi$es $hoi$es 8(/ 8(/ a. and andst ste einer iner 6. +lood +lood is stored stored at at what what tempera temperat%re t%re O a . 1 -6 C b. 2'-2(OC $. 2(-2)OC d. *)OC ). The following following are advantages of of stroma-free stroma-free hemoglobin, hemoglobin, EXCET EXCET!! a. ong ong shel shelff lif life e b. 9ery ery stab stable le $. :o anti antige geni ni$i $ity ty d. 3igh 3igh oy oyge gen n a;ni a;nity ty <. One of the follow following ing is an advanta advantage ge of per=%oro per=%oro$hem $hemi$als i$als!! a. +iol +iolog ogi$ i$ iner inertn tnes ess s b. 3igh 3igh oy oyge gen n a;ni a;nity ty $. >etent etentio ion n in in tis tiss%e s%es s d. #eep #eep-fr -free ee?e ?e stora storage ge . hi$h of of the follow following ing is are/ are/ roles roles// of platel platelets ets a. @ainta @aintain in vas$ vas$%la %larr integ integrit rity y b. Conver Converts ts proth prothro rombi mbin n to thrombi thrombin n $. Antimately Antimately involved involved in se$ond se$ondary ary hemostasis hemostasis d. "ll of the these se
1'.The minim%m n%mber of platelets reB%ired in a platelet $on$entrate prepared from whole blood by $entrif%gation is! a. &.& 1'11 b. *.' 1'1' $. &.& 1'1' d. *.' 1'11 11."dditive sol%tions are approved for blood storage for how many days a. (2 b. *& $. 21 d. ) 12.hen a man possesses a trait that is epressed in all his da%ghters b%t not in his sons, the trait is! a. "%tosomal dominant b. "%tosomal re$essive $. X-lin4ed dominant d. X-lin4ed re$essive 1*.Chara$teristi$ally, the trait is epressed in the father b%t is never passed from father to son instead all the da%ghters be$ome $arriers. The trait is said to be! a. "%tosomal dominant b. "%tosomal re$essive $. X-lin4ed dominant d. X-lin4ed re$essive 1(.The Drst imm%noglob%lin prod%$ed after epos%re to an antigen is a. Ag5 b. Ag" $. Ag@ d. AgE 1&.hi$h of the following has the most important role in maintaining the sigmoid shape of the normal oygen-hemoglobin disso$iation $%rve a. 3 $on$entration b. CO2 $. 2,*-#5 d. Temperat%re 16.The following are $omponents of nat%ral imm%nity, EXCET! a. Anta$t s4in b. + $ells $. @a$rophages d. :e%trophils 1).Cell-mediated imm%nity involves whi$h one of the following gro%p of $ells a. 1, 2, and * b. 1, *, and ( $. 2, *, and ( d. 1, 2, and ( 1<.The addition of one of the following will enhan$e the shelf-life of whole blood! a. 3eparin b. "denine $. :aCl
d. 5ly$erol 1.hi$h of the following $ells prod%$e imm%noglob%lins a. T $ells b. @a$rophages $. lasma $ells d. :at%ral 4iller $ells 2'.hi$h of the following $hara$teristi$s is :ot T>FE OG ": ":"@:E7TAC >E7O:7E a. 3as shorter lag phase b. 3as longer platea% $. "ntibodies $de$line slowly d. Ag@ predominate 21.hat is the possible blood type of the oHspring between the mating of O and homo?ygo%s " individ%als a. " only b. O only $. +oth of these d. :one of these 22.Af the mother and $hild are both blood type O, the father $annot be type! a. " b. + $. "+ d. "ll of these 2*.hat part of the antibody mole$%le Dts into a re$eptor on the phago$yti$ $ell a. Gab region b. G$ region $. 3inge region d. 9ariable region 2(.hi$h of the following is not a $omponent of the membrane atta$4 $omple a. C*b b. C6 $. C) d. C< 2&." p%n$t%red platelet $on$entrate bag m%st be %sed within 00000 ho%rs when stored at room temperat%re! a. ( b. 6 $. < d. 2( 26.The "+O genes o$$%py a lo$%s on! a. Chromosome b. Chromosome & $. Chromosome 1* d. Chromosome 6 2).hat is the possible blood type of the oHspring between the mating of O and "+ individ%als a. O b. "
$. "+ d. "ll of these 2<."ntigens of the "+O blood gro%p system! a. " and + b. " and O $. + and O d. ", +, and O 2.The patientIs spe$imen %sed in forward typing! a. >ed $ells b. 7er%m $. +oth of these d. :one of these *'.The patientIs spe$imen %sed in reverse typing! a. >ed $ells b. 7er%m $. +oth of these d. :one of these *1.hat is the possible genotype of the oHspring between a homo?ygo%s " and hetero?ygo%s + mating! a. +O b. OO $. "" d. "+ *2." false negative serologi$ rea$tion is sometimes $a%sed by e$ess amo%nt of reagent red $ells. This is $alled! a. EB%ivalen$e ?one b. ro?one $. ost ?one d. re$ipitation **.hi$h of the following spe$imens is most a$$eptable for ro%tine blood ban4 pro$ed%res a. 7er%m b. 5ran%lo$ytes $. hole blood d. +%Hy $oat *(." positive rea$tion in serologi$al testing in the blood ban4 is seen as! a. "ggl%tination b. 3emolysis $. Either of these d. :either of these *&.Af both parents are hetero?ygo%s >h positive, what is the per$entage the oHspring may be >h negative a. 1''J b. &'J $. 2&J d. )&J *6.Af the parents have O and "+ blood type, 2what is the per$entage the oHspring will have type + blood a. 1''J b. &'J
$. 2&J d. )&J *).hi$h imm%noglob%lins/ helps/ initiate the $lassi$al $omplement pathway a. Ag" and Ag# b. Ag@ only $. Ag5 and Ag@ d. Ag5 only *<.ro?one rea$tion in serologi$ testing is $orre$ted by! a. 3eat ina$tivation b. 7er%m dil%tion $. "dding more ser%m d. An$reasing p3 *.hat are the possible phenotypes of the oHspring from the mating of hetero?ygo%s +a nd hetero?ygo%s " individ%als a. ", +, and O b. ", +, "+, and O $. ", +, and "+ d. " and + ('.7ome blood gro%p antibodies $hara$teristi$ally hemoly?e appropriate red $ells in the presen$e of! a. Complement b. "nti$oag%lant $. reservatives d. "dditives (1.hat $onstit%tes a positive rea$tion in an aggl%tination inhibition pro$ed%re a. "ggl%tination b. 3emolysis $. a$4 of aggl%tination d. :one of these (2.hi$h of the following is an antigen presenting $ell "C/ a. Eosinophils b. @ono$ytes $. +asophils d. lasma $ells (*.The following are 4ey feat%res of a$B%ired imm%nity EXCET! a. :onspe$iD$ b. 3as memory $. "ttained later after $onta$t with antigen d. resent only in vertebrate ((.itho%t enhan$ement media, what imm%noglob%lin $lass will be able to bind $omplement a. Ag@ b. Ag5 $. Ag" d. AgE (&.Type A blood $ontains the following aaggl%tinogens on its red $ells! a. " b. +
$. +oth of these d. :one of these (6.The "+O ser%m gro%ping may not be valid when! a. Cold a%tosantibodies are present b. Ag@ alloantibodies are present $. atient has hypo- gammaglob%linemia d. "ll of these ().The notation +O represents a! a. 5enotype b. henotype $. Transferase d. +ombay phenotype (<.The + gene of the "+O system $odes for the prod%$tion of! a. G%$osyltransferase b. 5ala$tosyltransferase $. 5ala$tose d. :-a$etylgala$tosamine (.arents with blood gro%p " and "+ $annot prod%$e oHspring of gro%p! a. " b. + $. "+ d. O &'.hat isKare the possible phenotyepeKs of the oHspring from the mating of gro%p " andO individ%als a. " only b. O only $. " and O d. ", +, and O &1.The following are the re%lts of a forward typing! anti-" -/, anti-+ /. The epe$ted res%lts fro reverse gro%ping wo%ld be a. "1 $ells / + $ells / b. "1 $ells / + $ells -/ $. "1 $ells -/ + $ells / d. "1 $ells -/ +e $ells -/ &2.hi$h of the following is :OT tr%e abo%t anti-" and anti-+ a. They are well-developed at birth b. They are Lnat%rally o$$%rringM $. They are Ag@ soaggl%tinins d. They are rea$tive at $old temperat%re &*.0000000 %ses 4nown so%r$es of reagent antisera to dete$t antigens on an individ%alIs red blood $ells! a. Gorward Typing b. >everse typing $. #"T $rossmat$hing &(.hen are the possible phenotypes of the oHspring between the mating of O and "+ individ%als a. ", +, and O b. " and + $. "+ obnly d. ", +, "+, and O
&&.hat is the patientIs blood type if the patientIs red $ells do not aggl%tinate with anti-" and anti-+ antisera b%t his ser%m gives a positive rea$tion with both " 1 and + 4nown $ells a. " b. + $. "+ d. O &6."nti-3 is fo%nd in the sera of individ%als of gro%p! a. " b. + $. O d. Oh &).Af the parents have O and "+ blood type, what are the $han$es the oHspring will have type + blood a. 2&J b. &'J $. )&J d. 1''J &<."n individ%al inherited hh and "+ genes. hat is his red $ell phenotype a. " b. + $. "+ d. O &.The +ombay phenotype is $omposed of a geneti$ $ombination of! a. Oh b. 33 $. 33 d. 3h 6'.7er%m gro%ping te$hniB%e is performed only with this blood gro%p system! a. ewis b. @:7s $. "+O d. >h 61.7it%ation! @other is type O Child is type " "lleged father is type ". hat $on$l%sion $an be derived a. Child $o%ld not have been borne by mother b. :o paternal e$l%sion $an be indi$ated $. Child does not belong to both parents d. Child $o%ld not have been sired by alleged father 62.hi$h of the following >h antigens is the most imm%nogeni$ a. C b. # $. E d. C 6*.The following are the res%lts of typing with >h antisera! anti-# /, anti-C /, anti-E /, anti-$ -/, anti-e -/. hat is the phenotype a. >o b. >1 $. >y d. >?
6(."$B%ired + phenotype is s%spe$ted when! a. atient is type "+ b. Cells show wea4 rea$tion with anti-+ $. "nti-+ is fo%nd in ser%m d. "ll of these 6&.hi$h of these $hara$teri?es the rea$tion of >h negative phenotype a. :egative to both "nti-# and wea4 # test b. :egative to anti-# test $. :egative to anti-#, positive to wea4 # test d. ositive to wea4 # test 66.An wea4 # testing, the sample is in$%bated with! a. "35 at *)OC for 1&-*' min%tes b. "nti-# ant *)OC for 1&-*' min%tes $. "nti-#% at *)OC for 1&-*' min%tes d. 7aline at 2( OC for 1&-*' min%tes 6).The gly$olipid antigens prod%$ed by the red $ells appear to be e$l%sively made %p of! a. Type 1 $hains b. Type ( $hains $. Type * $hains d. Type 2 $hains 6<.The >h genes o$$%py a lo$%s on! a. Chromosome b. Chromosome & $. Chromosome 1 d. Chromosome 6 6."nti-3 le$tin, made form Ulex europaeus wo%ld aggl%tinate these $ells! a. 5ro%p Oh b. 5ro%p O $ells $. Either of these d. :either of these )'.+lood typing for "+O system and one of the following is ne$essary for blood transf%sion! a. @:7s b. +ombay $. d. >h )1.Af a #-positive person ma4es an anti-#, this person is probably a. artial # b. #-negative $. ea4 # as position eHe$t d. ea4 # d%e to transmissible genes )2.Etra$t of Dolichos biforus seeds is %sed to! a. Type +ombay gro%p b. Anhibit $omplement $. #iHerentiate gro%p "1 from gro%p " d. :one of these )*.The wea4 # phenotype is $onsidered! a. >h positive b. >h negative
$. Either of these d. :either of these )(.3ow may genes en$ode the following >h antiges! #, C, E, $, e a. One b. Two $. Three d. Go%r )&.Andivid%als who do not have the >h O #/ fa$tor are $lassiDed as! a. >hn%ll b. #F $. >h negative d. >h positive )6.The anti-rhes%s prod%$ed in laboratory animals by andsteiner and einer deDned a new antigen system $alled! a. b. ewis $. >h d. Nidd )).Af a gro%p DCe/dce man marries a dce/dce woman, what per$entage of their oHspring $an be epe$ted to be #-negative a. 1''J b. &'J $. 2&J d. )&J )<." re$ipient with # mosai$ phenotype m%st re$eive what blood in transf%sion a. >h positive blood b. >h negative blood $. Either :either ).+esides anti-# and anti-$, the established antibodies of the >h system are the following, EXCET! a. "nti-d b. "nti-C $. "nti-e d. "nti-E <'.The wea4 # may be $reated when the # gene is! a. "bsent on both $hromosomes b. Anherited from only one parent $. An trans position to the C gene d. resent on both $hromosomes <1.hi$h of these phenotypes shows the greatest freB%en$y among Gilipinos a. Type " >h / b. Type + >h / $. Type "+ >h / d. Type O >h / <2.Af a person has the geneti$ ma4e%p 3h, "O, ee, seese, what s%bstan$e will be fo%nd in the se$retions a. " s%bstan$e b. 3 s%bstan$e $. ea s%bstan$e
d. eb s%bstan$e <*." person with the geneti$ ma4e%p hh, "+, 7ese, has the following antigens and s%bstan$es! 1 " antigen 2 + antigen * 3 antigen ( " s%bstan$e & + s%bstan$e 6 3 s%bstan$e a. 1, 2, *, (, &, 6 b. 1, 2, (, & $. (, & d. (, &, 6 <(." person with the geneti$ ma4e%p 33, +O, sese, has the following antigens and s%bstna$es! 1 " antigen 2 + antigen * 3 antigen ( " s%bstan$e & + s%bstan$e 6- 3 s%bstan$e a. 1, 2, * b. 2, *, $. (, 6 d. (, &, 6 <&." person with the genti$ ma4e%p hh, OO, ele, 7ese, has the following antigens and s%bstan$es!
