PHARDOSE FINALS
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PREP 19: ISO-ALCOHOLIC ELIXIR -
CATEGORY: Non- Medicated Elixir
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SYNONYM: Iso-Elixir DESCRIPTION: clear, colorless hydro alcoholic solution USES: enerally used as a !ehicle "or dru #re#arations LABEL: $hite CONTAINER: %& 'l narro( 'outh a')er )ottle NON-OFFICIAL PREPARATION PREPARATION Material: *o'#ound orane s#irit Alcohol +lycerin Sucrose Saccharin Puried H&
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Eli!ir -
Hydroalcoholic Hydroalcoholic oral solutions -
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*lear, s(eetened and usually .a!ored to enhance taste N"#- Me$i%ate$ Eli!ir /ehicle o
Me$i%ate$ Eli!ir o 0sed "or the indication o" the acti!e inredient inredient Less suar than syru# 1he 'ore you 'as2 the taste3less e4ecti!e *ontains )oth (ater-solu)le and alcohol-solu)le alcohol-solu)le co'#onents A$&'#%ti(e "l(e#t: lycerine 5 #ro#ylene lycol
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6&-67 alcohol content3sel"#reser!in 8-9&73li'it
Met)"$ "* Pre+arati"#: Si,+le S"l# ./ o a0itati"# Solutes are dissol!ed in the sol!ent )y 'ixin Alcohol-solu)le inredients are dissol!ed in alcohol $ater-solu)le $ater-solu)le are dissol!ed in #uried (ater A:ueous #ortion is added to the alcoholic #ortion Su)se:uent addition o" the s#ecied !ehicle +enerally !ehicles "or #har'aceutical #re#arations re:uirin a s#ecied alcoholic strenth Allli0ati"#: deter'ine the !olu'es o" hih and lo( alcoholic elixirs Hi0) t" l". 23
T)e l".-al%")"li% eli!ir .a all".e$ t" ta#$ *"r 45 )"'r6 7)8 o 1o 1o ensure ensure the saturation saturation o" the hydroalcoholic sol!ent and #er'it the oil lo)ules to coalesce; 7)8 t'ri$it8 "%%'r .)e# a;'e"' "l# i a$$e$ t" t)e al%")"li% "l# Partial #reci#itation o occurs due to reduced alcoholic content o" the nal #re#aration;
PROCEDURE
1er#in Hydrate- acti!e inredient Alcohol- co-sol!ent Orane Peel tincture- .a!orant enBaldehyde- #reser!ati!e +lycerin- s(eetenin aent Syru#- s(eetenin aent Puried (ater, :s ad- !ehicle
Lo( Alcoholic Elixir 6; *o')ine alcohol, lycerine, and <;8 'l o" #uried H&; Stir; ; = co'#ound orane s#irit and stir; *o!er it and let it stand "or 9 hours; %; A"ter standin, lter the sol>n until clear; 9; = sucrose to the ltrate and stir; 8; = su?cient H& to 'a2e the re:uired !olu'e;
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Hih Alcoholic Elixir 6; Mix co'#ound orane s#irit, saccharin, and <;8 'l o" alcohol; ; Stir in lycerine; %; = su?cient alcohol to 'a2e the re:uired !olu'e;
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Iso-Alcoholic Elixir
6; Mix 68 'l o" lo( alcoholic elixir and 68 'l hih alcoholic elixir;
PREP 4<: TRERPIN HYDRATE ORAL SOLUTION CATEGORY: Medicated Elixir
SYNONYMS: Elixir 1er#in Hydrate, 1er#inol Elixir, 1er#in Hydrate Elixir DESCRIPTION: colorless solution (@ striations, containin 9%7 o" alcohol USES: used as an ex#ectorant LABEL: $hite CONTAINER: %& 'l narro( 'outh a')er )ottle OFFICIAL PREPARATION Material:
U+"# $il'ti"#= i* %"#%e#trati"# "* t)e ter+i# )8$rate $e%reae> it .ill +re%i+itate Ea%) 1<< ,l "* ter+i# )8$rate "ral "l'ti"# %"#tai# #lt 16?@ 0 a#$ #,t 16 0 "* ter+i# )8$rate Ol$ #a,e: 1er#in Hydrate Oral Solution Ne. #a,e: 1er#in Hydrate Elixir H". $"e tal% ."r a a lter ai$ t" re,"(e t'ri$it8 o It tends to a)sor) the excess o" oils and assist in their re'o!al "ro' sol>n; +lycerine and #ro#ylene ser!e as a !iscosity )uilder and a sta)iliBer;
PROCEDURE: 6; Pul!eriBe ter#in hydrate in a 'ortar usin #estle; ; In a )ea2er, stir in ter#in hydrate to the alcohol; %; Se:uentially = orane #eel tincture, )enBaldehyde,lycerine, and syru# and stir a"ter e!ery addition; 9; = enouh (ater to 'a2e re:uired !olu'e;
8; I" the resultin #roduct is tur)id, lter until clear;
PREP 41: COMPOUND ORANGE SPIRIT CATEGORY: Non- Medicated S#irit SYNONYM: S#iritus Auranti *o'#ositus DESCRIPTION: clear, yello( orne sol>n (@ the odor and taste o" orane USES: as a .a!orin aent LABEL: $hite CONTAINER: %& 'l narro( 'outh a')er )ottle OFFICIAL PREPARATION Material: Orane oil Le'on oil *oriander oil Anise oil Alcohol
SPIRITS -
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Cessences Are alcoholic or hydroalcoholic solutions o" aro'atic !olatile 'aterial Hih alcoholic concentration &7 due to 0reater "l'ilit8 "* t)e ("latile i#0re$ie#t i# al%")"l rat)er t)a# i# H4<6 Acti!e inredient solid, li:uid or as 0sed as .a!orin aent or 'edicinal !alue *an )e a##lied externally, inhaled, or ta2en orally
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Dilutin the s#irit (@ (ater
)e"ore oral inta2e3 reduces its #unent taste Methods Si,+le S"l'ti"#o solutes are dissol!ed in sol!ent Ma%erati"#lea!es are soa2ed in alcohol to extract desired !olatile su)s Ditillati"# ./Fer,e#tati"#suar in the ra( 'aterial is consu'ed )y the added yeast Gsaccharomyces cerevisiae) resultin to the "or'ation o" alcohol alcohol is then se#arated )y heatin the 'aterial so that alcohol !a#oriBes rst, cools and condenses to "or' clear dro#s o" distillate; - Ea%) 1<< ,l "* %",+"'#$ "ra#0e +irit %"#tai# #lt 4? ,l a#$ #,t @< ,l "* t)e ,i!e$ "il -
PROCEDURE: 6; In a )ea2er, #lace 6;<8 'l alcohol; ; Stir in orane oil, le'on oil, coriander oil and anise oil, until the oils are all dissol!es thorouhly
%; Filter the resultin sol>n until clear and = alcohol to 'a2e the re:uired !olu'e;
PREP 44: PEPPERMINT SPIRIT CATEGORY: Medicated S#irit SYNONYMS: essence o" #e##er'int, s#iritus 'enthos #i#eritas DESCRIPTION: a )rilliant reen solution USES: used as a car'inati!e LABEL: $hite CONTAINER: %& 'l narro( 'outh a')er )ottle OFFICIAL PREPARATION Material: Pe##er'int oil Pe##er'int lea!e Alcohol, :s ad - In each 6&& 'l, nlt ;& 'l and n't 66;& 'l o" #e##er'int oil
; Stir in #e##er'int oil to the ltrate and add alcohol to 'a2e the re:uired !olu'e;
PREP 4@: AROMATIC AMMONIA SPIRIT CATEGORY: Medicated S#irit SYNONYMS: S'ellin salts, Sal /olatile, Salt o" Hartshorn DESCRIPTION: a colorless to yello( solution (ith the odor o" a''onia USE: #re!ention o" synco#e LABEL: Red CONTAINER: %& 'l narro( 'outh a')er )ottle OFFICIAL PREPARATION Material: Manesiu' *ar)onate Stron A''onia Solution Le'on Oil Mystic Oil La!ender Oil Alcohol
PROCEDURE: 6; Re'o!e ste's "ro' the #e##er'int lea!es as 'uch as #ossi)le and tear the' into coarse #articles; ; In a )ea2er, 'acerate the lea!es in & 'l o" #uried (ater "or 6 hour; %; *ollect the lea!es and stronly ex#ress the' usin lter #a#er; 9; Macerate the 'oist lea!es in & 'l o" alcohol "or hours (ith "re:uent aitation; 8; Filter throuh 'uslin cloth or lter #a#er;
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Puried $ater, :s ad Each 6&& 'l o" the #re#
contains nlt 6;< and n't ;6 o" the total NH% content - a hydroalcoholic solution that is intended to )e inhaled - nlt %;8 and n't 9;8 o" GNH9J*O%
PROCEDURE: 16 In a )ea2er, co')ine stron a''onia solution and 'l #uried (ater and dissol!e
a''oniu' car)onate; Stir and let it stand "or 9 hours; 46 In another )ea2er, dissol!e all the !olatile oils in alcohol; @6 Slo(ly co')ine the t(o solutions;
56 = su?cient a'ount o" #uried (ater to 'a2e the re:uired !olu'e;
